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The skeleton: Endocrine regulator of phosphate homeostasis
Current Osteoporosis Reports, 2008Phosphorus is an essential element in skeletal development, bone mineralization, membrane composition, nucleotide structure, and cellular signaling. Phosphate, the principal form in which phosphorus is found in the body, is regulated by the complex interplay of the hormones parathyroid hormone (PTH), calcitriol (1,25[OH](2) vitamin D(3)), and ...
Máire E, Doyle, Suzanne M, Jan de Beur
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Phosphate Homeostasis in Cimetidine Treated Uremic Dogs
1982More than a decade ago, a secondary hyperparathyroidism (HPTH) was postulated to be directed at the maintenance of phosphate homeostasis in chronic uremia (1). Each decrement in glomerular filtration rate would be associated with transient hyperphosphatemia, hypocalcemia and an increase in PTH secretion.
A I, Jacob +4 more
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[Phosphate homeostasis and oral diseases].
Clinical calcium, 2016FGF23 produced mainly by osteocytes plays a central role in phosphate homeostasis by increasing the renal phosphate excretion and suppressing the vitamin D activation. Mutations in FGF23 and its regulatory molecules such as PHEX, DMP1, and FAM20C have been shown to be responsible for hereditary hypophosphatemic diseases.
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Phosphate Homeostasis Regulatory Mechanisms
2012Clemens Bergwitz, Harald Jüppner
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