Results 1 to 10 of about 4,830 (163)

Effect of APOB polymorphism rs562338 (G/A) on serum proteome of coronary artery disease patients: a “proteogenomic” approach [PDF]

Scientific Reports, 2021
In the current study, APOB (rs1052031) genotype-guided proteomic analysis was performed in a cohort of Pakistani population. A total of 700 study subjects, including Coronary Artery Disease (CAD) patients (n = 480) and healthy individuals (n = 220) as a ...
Muneeza Zafar, Munazza Raza Mirza, Fazli Rabbi Awan, Muhammad Tahir, Rabia Sultan, Misbah Hussain, Ahmed Bilal, Shahid Abbas, Martin R. Larsen, Muhammad Iqbal Choudhary, Imran Riaz Malik   +10 more
doaj   +2 more sources

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Journal of Clinical Investigation, 2022
Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver cancer
S. Kawamura, Y. Matsushita, Shigeyuki Kurosaki, Mizuki Tange, N. Fujiwara, Y. Hayata, Y. Hayakawa, Nobumi Suzuki, M. Hata, Mayo Tsuboi, T. Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Y. Hoshida, Atsushi Umemura, A. Eguchi, T. Ikenoue, Y. Hirata, M. Uesugi, R. Tateishi, K. Tateishi, M. Fujishiro, K. Koike, Hayato Nakagawa   +25 more
semanticscholar   +1 more source

Transmembrane Protein 68 Functions as an MGAT and DGAT Enzyme for Triacylglycerol Biosynthesis

International Journal of Molecular Sciences, 2023
Triacylglycerol (TG) biosynthesis is an important metabolic process for intracellular storage of surplus energy, intestinal dietary fat absorption, attenuation of lipotoxicity, lipid transportation, lactation and signal transduction in mammals ...
Yu Wang, Fansi Zeng, Zheng-Xiao Zhao, Lin He, Xiaohong He, H. Pang, Feifei Huang, Pingan Chang   +7 more
semanticscholar   +1 more source

Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion [PDF]

, 2018
Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive
Ferreira, Raphael, Nielsen, Jens, Siewers, Verena, Teixeiraa, Paulo Goncalves   +3 more
core   +1 more source

Interplay between phospholipids and digalactosyldiacylglycerol in phosphate limited oats [PDF]

, 2009
Phosphate is an essential nutrient. In most soils it is limiting, which has resulted in that phosphate is supplied as fertilizer to increase crop yield.
Tjellström, Henrik
core   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death*

Journal of Biological Chemistry, 2009
Deletion of the acyltransferases responsible for triglyceride and steryl ester synthesis in Saccharomyces cerevisiae serves as a genetic model of diseases where lipid overload is a component.
J. Garbarino, M. Padamsee, L. Wilcox, Peter Oelkers, Diana M D'Ambrosio, Kelly V. Ruggles, N. Ramsey, O. Jabado, Aaron R. Turkish, S. Sturley   +9 more
semanticscholar   +1 more source

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites [PDF]

, 2014
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and production of essential lipid-derived molecules.
Gross, Steven P., Parton, Robert G., Pol, Albert   +2 more
core   +1 more source

Lipids under stress - a lipidomic approach for the study of mood disorders [PDF]

, 2015
The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of ...
Antonny, Arevalo, Bazinet, Bessa, Björkhem, Bligh, Bozek, Brügger, Buchenauer, Catania, Cermenati, Cerqueira, Cerruti, Chan, Chang, Choi, Chuang, Dawson, De Kroon, Delisi, Di Paolo, Di Paolo, Dias, Dias-Ferreira, Dietschy, Dunkley, Fahy, Fahy, Feder, Giovacchini, Green, Green, Guan, Gulbins, Han, Hannun, Hartmann, Heverin, Holthuis, Holthuis, Huang, Karran, Kassas, Kay, Kielkowska, Kim, Kloda, Klose, Kodigepalli, Kornhuber, Lam, Lamaziere, Lee, Lev, Levant, Little, Liu, Lupien, Lütjohann, Maceyka, Malcher-Lopes, Mapstone, McMahon, McNamara, Mesmin, Miller, Morel, Mouritsen, Movahed, Müller, Nestler, Nestler, Nguyen, Nicolson, Oliveira, Oliveira, Oliveira, Ortolani, Pinto, Piomelli, Popoli, Prasad, Prasad, Puri, Radhakrishnan, Ricart-Jané, Roozendaal, Sanchez, Sanchez-Mejia, Schauder, Schultz, Shevchenko, Simons, Simons, Sousa, Sousa, Sousa, Sousa, Subramanian, Sundaram, Takamori, Thatcher, Tiemeier, Van Meer, Vetrivel, Wakelam, Walter, Wenk, Wenk, Williamson, Wymann, Yang, Zhang, Zhang, Zolov   +114 more
core   +1 more source

Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

Frontiers in Oncology, 2023
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
semanticscholar   +1 more source