Results 1 to 10 of about 4,396 (136)

Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice. [PDF]

FASEB J
Pan et al. demonstrate that disruption of hepatic insulin signaling by insulin receptor (IR) substrate (IRS1/2) deletion led to impaired PI3K‐AKT signaling, causing increased Foxo1 activation and TGF‐β1 expression, which dysregulated the expression of the key enzymes involving phospholipid biosynthesis and remodeling.
Pan Q, Pan M, Ai W, Yang W, Jiang W, Han X, Guo S.   +6 more
europepmc   +2 more sources

Effect of APOB polymorphism rs562338 (G/A) on serum proteome of coronary artery disease patients: a “proteogenomic” approach

Scientific Reports, 2021
In the current study, APOB (rs1052031) genotype-guided proteomic analysis was performed in a cohort of Pakistani population. A total of 700 study subjects, including Coronary Artery Disease (CAD) patients (n = 480) and healthy individuals (n = 220) as a ...
Muneeza Zafar, Munazza Raza Mirza, Fazli Rabbi Awan, Muhammad Tahir, Rabia Sultan, Misbah Hussain, Ahmed Bilal, Shahid Abbas, Martin R. Larsen, Muhammad Iqbal Choudhary, Imran Riaz Malik   +10 more
doaj   +1 more source

Interplay between phospholipids and digalactosyldiacylglycerol in phosphate limited oats [PDF]

, 2009
Phosphate is an essential nutrient. In most soils it is limiting, which has resulted in that phosphate is supplied as fertilizer to increase crop yield.
Tjellström, Henrik
core   +1 more source

Lipidomics in Health and Diseases - Beyond the Analysis of Lipids [PDF]

, 2014
published_or_final_versio
Fan, P, Li, M, Wang, Y
core   +1 more source

Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]

, 2020
Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian, Bahethi, Rohini, Beule, Dieter, Choi, Murim, Eisenhofer, Graeme, Liebisch, Gerhard, Messerschmidt, Clemens, Obermayer, Benedikt, Peitzsch, Mirko, Scholl, Ute I., Schrade, Petra, Seidel, Eric, Walenda, Gudrun, Wallace, Paal, Yoo, Taekyeong   +14 more
core   +2 more sources

Lipids under stress - a lipidomic approach for the study of mood disorders [PDF]

, 2015
The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of ...
Antonny, Arevalo, Bazinet, Bessa, Björkhem, Bligh, Bozek, Brügger, Buchenauer, Catania, Cermenati, Cerqueira, Cerruti, Chan, Chang, Choi, Chuang, Dawson, De Kroon, Delisi, Di Paolo, Di Paolo, Dias, Dias-Ferreira, Dietschy, Dunkley, Fahy, Fahy, Feder, Giovacchini, Green, Green, Guan, Gulbins, Han, Hannun, Hartmann, Heverin, Holthuis, Holthuis, Huang, Karran, Kassas, Kay, Kielkowska, Kim, Kloda, Klose, Kodigepalli, Kornhuber, Lam, Lamaziere, Lee, Lev, Levant, Little, Liu, Lupien, Lütjohann, Maceyka, Malcher-Lopes, Mapstone, McMahon, McNamara, Mesmin, Miller, Morel, Mouritsen, Movahed, Müller, Nestler, Nestler, Nguyen, Nicolson, Oliveira, Oliveira, Oliveira, Ortolani, Pinto, Piomelli, Popoli, Prasad, Prasad, Puri, Radhakrishnan, Ricart-Jané, Roozendaal, Sanchez, Sanchez-Mejia, Schauder, Schultz, Shevchenko, Simons, Simons, Sousa, Sousa, Sousa, Sousa, Subramanian, Sundaram, Takamori, Thatcher, Tiemeier, Van Meer, Vetrivel, Wakelam, Walter, Wenk, Wenk, Williamson, Wymann, Yang, Zhang, Zhang, Zolov   +114 more
core   +1 more source

Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion [PDF]

, 2018
Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive
Ferreira, Raphael, Nielsen, Jens, Siewers, Verena, Teixeiraa, Paulo Goncalves   +3 more
core   +1 more source

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites [PDF]

, 2014
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and production of essential lipid-derived molecules.
Gross, Steven P., Parton, Robert G., Pol, Albert   +2 more
core   +1 more source

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency [PDF]

, 2005
Affiliation: CHU-Sainte-Justine, Université de MontréalTransport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are ...
Drouin, Éric, Levy, Emile, Marcil, Valérie, Peretti, Noël   +3 more
core   +2 more sources

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources