Results 31 to 40 of about 4,293 (162)

Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice [PDF]

, 2020
Background: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death in the world. Choline deficiency has been well studied in the context of liver disease; however, less is known about the effects of choline supplementation ...
Allende, Daniela S., Brown, Amanda L., Conrad, Kelsey, Gromovsky, Anthony D., Helsley, Robert N., Neumann, Chase K., Owens, A. Phillip, Tranter, Michael, Zhang, Renliang   +8 more
core   +2 more sources

Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis [PDF]

, 2008
Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA.
Coleman, Rosalind, Lewin, Tal, Wendel, Angela   +2 more
core   +2 more sources

Proteome analysis develops novel plasma proteins classifier in predicting the mortality of COVID‐19

Cell Proliferation
COVID‐19 has been a global concern for 3 years, however, consecutive plasma protein changes in the disease course are currently unclear. Setting the mortality within 28 days of admission as the main clinical outcome, plasma samples were collected from ...
Yifei Zeng, Yufan Li, Wanying Zhang, Huidan Lu, Siyi Lin, Wenting Zhang, Lexin Xia, Huiqun Hu, Yuanlin Song, Feng Xu   +9 more
semanticscholar   +1 more source

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

Cancer therapy‐related cardiotoxicity is associated with distinct alterations of the myocardial lipidome

European Journal of Heart Failure, EarlyView.
Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun, Anna Foryst‐Ludwig, Ulf Landmesser, István Baczkó, Hendrik Milting, Ulrich Kintscher, Niklas Beyhoff   +6 more
wiley   +1 more source

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover [PDF]

, 2016
Lysosomal acid lipase (LAL) is essential for the clearance of endocytosed cholesteryl ester and triglyceride-rich chylomicron remnants. Humans and mice with defective or absent LAL activity accumulate large amounts of cholesteryl esters and triglycerides
Du, Hong, Eichmann, Thomas O., Fickert, Peter, Grumet, Lukas, Haemmerle, Guenter, Kratky, Dagmar, Lass, Achim, Leopold, Christina, Moustafa, Tarek, Radovic, Branislav, Romauch, Matthias, Taschler, Ulrike, Yan, Cong, Zechner, Rudolf, Zierler, Kathrin A., Zimmermann, Robert   +15 more
core   +1 more source

MBOAT7 in liver and extrahepatic diseases [PDF]

, 2023
MBOAT7 is a protein anchored to endomembranes by several transmembrane domains. It has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated fatty acids.
Caddeo A., Maurotti S., Spagnuolo R.
core   +1 more source

Myelin Lipid Composition in the Central Nervous System Is Regionally Distinct and Requires Mechanistic Target of Rapamycin Signaling

Glia, EarlyView.
Brain oligodendrocytes have lower rates of cholesterol synthesis and higher rates of lipoprotein uptake than spinal cord oligodendrocytes. Myelin lipid content is higher in CNS regions with larger average axon diameter. Brain and spinal cord myelin cholesterol content is innately different, while myelin fatty acid content can be modulated by fiber ...
Marie L. Mather, Angelina V. Evangelou, Jennifer N. Bourne, Wendy B. Macklin, Teresa L. Wood   +4 more
wiley   +1 more source

Highlights of recent progress in plant lipid research [PDF]

, 2009
Raw fossil material reserves are not inexhaustible and as prices continue to raise it is necessary to find new sources of alternative and renewable energy.
Andersson, Arent, Bates, Burgal, Chen, Damude, Dietrich, Dietrich, Durrett, Dyer, E. Cahoon, E. Heinz, Eastmond, Fauconnier, Fulda, Goepfert, Greer, Höfer, Imamura, J. Dyer, Joubès, K. Chapman, Kilaru, Krinke, Lardizabal, Li, Li, Michaelson, Molina, Mosblech, Mueller, Napier, Nishikawa, P. Eastmond, Panikashvili, Pata, R. Lessire, Ritter, Shockey, Slama, Teaster, van Leeuwen, Xiong, Zaüner   +43 more
core   +1 more source

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Nature Communications, 2020
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family.
Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, Koji Nishi, Catherine C. Y. Chang, Ta-Yuan Chang, T. Luo, Lei Chen   +9 more
semanticscholar   +1 more source