Results 271 to 280 of about 156,498 (339)

Liposomal 188Rhenium Plus Macrophage Depletion Enhances Anti‐PD‐L1 Efficacy and B Cell Infiltration Against Lung Metastatic Cancer

open access: yesCancer Science, EarlyView.
This study demonstrates that combining liposomal Rhenium‐188 (Lipo‐Re188) with macrophage depletion and anti–PD‐L1 therapy enhances therapeutic efficacy against lung metastatic colon cancer. The triple therapy promotes B cell infiltration, restores T cell function, and suppresses MDSC, creating a tumor‐suppressive immune microenvironment.
Shin‐Yi Liu   +3 more
wiley   +1 more source

Comparative Cytokine and Histology Studies on HPV and Other Viral Vaccinations: No Pathogenicity of HPV Vaccine Adjuvants

open access: yesCancer Science, EarlyView.
Anti‐HPV vaccine activists claimed that aluminum (Al) adjuvants in HPV vaccines could cause immune abnormalities, leading to neurological diseases. We evaluated the cytokine and histology profiles following administrations of HPV vaccines and other viral vaccines containing adjuvants.
Reona Shiro   +9 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

open access: yesCell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai   +13 more
wiley   +1 more source

Plasma sphingolipids predict advanced liver fibrosis development in patients with type 2 diabetes

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Patients with type 2 diabetes (T2D) are at an elevated risk of developing metabolic dysfunction‐associated steatotic liver disease (MASLD), with a significant likelihood of progression to advanced liver fibrosis (AF)—a stage linked to adverse outcomes.
Sarah Béland‐Bonenfant   +10 more
wiley   +1 more source

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