Results 281 to 290 of about 160,241 (340)

Nanoengineered photosensitizers for photodynamic priming to overcome P‐glycoprotein‐mediated multidrug resistance

Photochemistry and Photobiology, EarlyView.
Verteporfin's subcellular localization governs its ability to deplete ATP. LysoPC‐conjugated VP accumulates in lysosomes and spares mitochondria, while liposomal and NanoVP formulations target mitochondria, where light activation triggers membrane depolarization and ATP depletion, overcoming resistance seen with free‐form VP. Abstract P‐glycoprotein (P‐
Idrisa Rahman, Anju Meda, Kaitlyn A. Moore, Payal Srivastava, Anika Dasgupta, Andaleeb Sajid, Suresh V. Ambudkar, Huang‐Chiao Huang   +7 more
wiley   +1 more source

Liposomal antimicrobials in the fight against bacterial and fungal pathogens: Clinical successes and development challenges. [PDF]

Int J Pharm X
Kenaan HT, Duncan RM, Al-Jamal WT, Jones DS, Andrews GP, Gilmore B, Yardley V, Farrington N, Stott KE, Lawrence D, Jarvis JN, Harrison TS, Robinson S, Ribeiro I, Hope W, Tian Y.   +15 more
europepmc   +1 more source

Design of High‐Diacylglycerol and Lecithin Soybean Seed Oil Using GmPDATs and GmDGATs Knockout via a CRISPR‐Cas9 System

Plant Biotechnology Journal, EarlyView.
Ying Zhao, Binshuo Zhang, Huilin Tian, Yang Liu, Yifan Cui, Sihui Wang, Zhenbang Hu, Mingliang Yang, Qingshan Chen   +8 more
wiley   +1 more source

Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

Transfusion, EarlyView.
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Gürkan Bal, Maia Dzamashvili, Zhuoran Li, Magda Babina, Nidal Toman, Abdulgabar Salama   +5 more
wiley   +1 more source

Plasmalogens as biomarkers and therapeutic targets. [PDF]

J Lipid Res
Curran CS, Remaley AT, Torabi-Parizi P.
europepmc   +1 more source

GPR183‐mediated activation of PI3K is a potential biomarker for immunotherapy in lung cancer

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Anti‐PD1 treatment and PI3Kγ inhibition had remarkable therapeutic performance on CD4+ Tcm and CD4+ Tn in lung cancer through potential regulation of PI3K pathway with participation of GPR183. Abstract Background As one of commonly used immune checkpoint inhibition therapies, PD1 monoclonal antibodies exhibit a promising cancer immunotherapy approach ...
Ling Ye, Nannan Zheng, Fangming Liu, Huirong Fu, Yifei Liu, Ying Yang, Ruixue Qi, Duojiao Wu, Lin Shi, Dongli Song   +9 more
wiley   +1 more source

Causal Relationships Among Lifestyle, Lipidome, and Polycystic Ovary Syndrome: A Mendelian Randomization Study. [PDF]

Int J Womens Health
Kou X, Jing X.
europepmc   +1 more source

Permeability of 16 Straight‐ and Branched‐Chain Parabens Using the Caco‐2 Assay

Journal of Applied Toxicology, Volume 46, Issue 2, Page 652-668, February 2026.
ABSTRACT The in vitro intestinal permeability of straight‐ and branched‐chain parabens has not been extensively investigated. Sixteen parabens were tested in the Caco‐2 assay. Passive diffusion was measured using PAMPA. The transport of the MCT1 substrate, p‐coumaric acid, as well as propylparaben and isopropylparaben, was investigated.
Nicola J. Hewitt, Manuela Mayer, Andreas Schepky, Corie Ellison   +3 more
wiley   +1 more source

The Effect of Synthetic Cow Urine on Microorganisms and Their Potential Phosphorus Mining Activity in Rhizosphere and Bulk Soil

Journal of Plant Nutrition and Soil Science, Volume 189, Issue 1, Page 69-80, February 2026.
ABSTRACT Background and aims Soil microbes adapt to varying nutrient inputs by modifying their utilization strategies, with root exudates and animal urine serving as key carbon (C) and nutrient sources in grasslands. Nonetheless, the specific mechanisms by which cow urine and root exudates influence microbial community and resource utilization remain ...
Manisha Koirala, Yang Ding, Osman Mustafa, Lichao Fan, Tianpeng Li, Nataliya Bilyera, Callum C. Banfield, Michaela A. Dippold   +7 more
wiley   +1 more source

Lipidomic profiling reveals systemic serum lipid remodeling induced by dexamethasone in mice. [PDF]

Front Mol Biosci
Zhang A, Wang Z, Ji J.
europepmc   +1 more source