Results 281 to 290 of about 31,592 (359)

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn   +6 more
wiley   +1 more source

Metabolic Biomarkers of Liver Failure in Cell Models and Patient Sera: Toward Liver Damage Evaluation In Vitro. [PDF]

open access: yesInt J Mol Sci
Rentschler S   +6 more
europepmc   +1 more source

Protein import into bacterial endosymbionts and evolving organelles

open access: yesThe FEBS Journal, EarlyView.
The acquisition of bacterial endosymbionts by ancient host cells followed by massive adaptation of the partners gave rise to mitochondria and plastids. Today, various systems with younger and less integrated endosymbionts provide insights into the initial steps in the endosymbiont to organelle transition.
Megan E. S. Sørensen   +3 more
wiley   +1 more source

Editorial: Metabolomics perspectives for clinical medicine, volume II. [PDF]

open access: yesFront Mol Biosci
Dudzik D   +3 more
europepmc   +1 more source

Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis

open access: yesThe FEBS Journal, Volume 292, Issue 7, Page 1781-1797, April 2025.
Cathepsin D (CTSD), primarily intracellular, is crucial for normal cellular processes but can be secreted extracellularly in diseases like metabolic dysfunction‐associated steatohepatitis (MASH), associated with liver fat accumulation. Our study investigated how inhibiting CTSD inside and outside of cells influences lipid levels in a mouse model that ...
Isabeau Vermeulen   +13 more
wiley   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

open access: yesThe FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi   +16 more
wiley   +1 more source

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