Results 201 to 210 of about 10,007 (332)

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, EarlyView.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Central nervous system involvement in cardiac amyloidosis: Redefining the heart‐brain axis

European Journal of Clinical Investigation, EarlyView.
Central nervous system involvement in cardiac amyloidosis. Amyloidosis is a systemic disease that can directly affect the central nervous system. Furthermore, the amyloid cardiomyopathy can indirectly affect the central nervous system by inducing systemic hypoperfusion and increasing the risk of acute ischaemic stroke.
Domenico Mario Giamundo, Giuliano Cassataro, Stefano Ministrini, Simon F. Stämpfli   +3 more
wiley   +1 more source

Transport of exogenous fluorescent phosphatidylserine analogue to the Golgi apparatus in cultured fibroblasts. [PDF]

, 1991
Toshihide Kobayashi, Yasuhiko Arakawa
openalex   +1 more source

Strategies for enhancing the therapeutic targeting of phosphatidylserine in oncological disorders and viral infections

, 2015
Iona Shu-Yi Easthope
openalex   +2 more sources

Anti-Phosphatidylserine/Prothrombin Antibodies Are Associated with Adverse Pregnancy Outcomes [PDF]

, 2015
Polona Žigon, Katja Perdan Pirkmajer, Matija Tomšič, Tanja Kveder, Borut Božič, Snežna Sodin Šemrl, Saša Čučnik, Aleš Ambrožič   +7 more
openalex   +1 more source

Integrated biomarker landscape for the early detection and management of calcific aortic valve disease

European Journal of Clinical Investigation, EarlyView.
Calcific aortic valve disease (CAVD), the leading valvular disorder in older adults, progresses from sclerosis to severe stenosis without effective medical therapies, making early non‐invasive detection essential. Circulating and mechanistic biomarkers reflect core pathogenic axes, including lipid oxidation, inflammation, mineral metabolism ...
Alberto Cook‐Calvete, Silvia Moreta, Maria Delgado‐Marin, Blanca Fernandez‐Rodriguez, Carlos Zaragoza, Marta Saura   +5 more
wiley   +1 more source

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells [PDF]

, 2017
Slavica Vučković, Kate Vandyke, David A. Rickards, Padraig McCauley Winter, Simon H. J. Brown, Todd W. Mitchell, Jun Liu, Jun Lü, Philip W. Askenase, Elizabeth Yuriev, Ben Capuano, Paul A. Ramsland, Geoffrey R. Hill, Andrew C.W. Zannettino, Andrew T. Hutchinson   +14 more
openalex   +1 more source

Phosphatidylserin-Antikörper [PDF]

, 2019
openaire   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source