Results 241 to 250 of about 8,775 (288)

The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or Rac1 is the actual substrate inactivated by RacGAP1 ...
Pavlina Dubois, Yann Ferrandez, Clara Rey, Cyril Pages, Agata Nawrotek, Jacqueline Cherfils   +5 more
wiley   +1 more source

Not-So-Rare Defects of RBC Lipidic Composition: Four New Cases of Flippase Deficiency Due to ATP11C Mutations. [PDF]

Int J Mol Sci
Fermo E, Trombetta E, Marcello AP, Vercellati C, Ferrari GM, Zaninoni A, Brancaleoni V, Di Pierro E, Beneventi S, Tornese M, Fattizzo B, Casini T, Corti P, Bianchi P.   +13 more
europepmc   +1 more source

Phosphorylation disrupts the interaction between the intrinsically disordered region of the oncogenic NDRG1 and lipid vesicles

Protein Science, Volume 35, Issue 3, March 2026.
Abstract NDRG1 is a multifunctional regulatory human protein implicated in crucial cellular processes and acting as a central hub of a cancer‐related interactome. In lung cancer, increased NDRG1 expression is associated with resistance to chemotherapy and is linked to the cellular response to nickel, a known tumor driver in air pollution.
Noemi Carosella, Chiara Pastorello, Jehan Waeytens, Ylenia Beniamino, Valentina Roncassaglia, Lucrezia Serra, Vincent Raussens, Elisabetta Mileo, Stefano Ciurli, Barbara Zambelli   +9 more
wiley   +1 more source

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

Advances in Engineered Extracellular Vesicles for the Treatment of Atherosclerosis and Atherothrombosis – Next‐Generation Cardiovascular Nanomedicine

Small Structures, Volume 7, Issue 3, March 2026.
Exosomes (small extracellular vesicles) are nanosized vesicles produced naturally by living cells. They can be engineered by various techniques to deliver biologically active molecules to injury sites in atherosclerosis and atherothrombosis. Therefore, an exosome‐based multifunctional nanomedicine for the diagnosis, monitoring, and treatment of these ...
Tuan Huu Nguyen, Nhu Thao Huynh, Be'eri Niego, Christoph E. Hagemeyer, Rong Xu   +4 more
wiley   +1 more source

Macrophages rescue cells from ferroptotic death. [PDF]

Cell Death Dis
Hefetz R, Lianski S, Ghantous L, Volman Y, Sadovsky Y, Beharier O, Rachmilewitz J.   +6 more
europepmc   +1 more source

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice

Aging Cell, Volume 25, Issue 3, March 2026.
This study shows that oxidative changes in oocytes from aged female mice lead to lipid droplet accumulation and altered energy and retinoid metabolism. These changes persist in embryonic organs, triggering antioxidant responses in lipid‐rich tissues. Remarkably, altered profiles are transmitted across generations, reaching third generation, suggesting ...
Hafsa Gulzar, Richard Musson, Simona Bisogno, Lulu Alluhaibi, Alexey Maximenko, Ewelina Bik, Małgorzata Barańska, Joanna Depciuch, Grażyna E. Ptak   +8 more
wiley   +1 more source

The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial. [PDF]

Nutr J
Friling M, Jackson PA, Kennedy D, Dodd F, Smith E, Lavie A, Lopresti A, Ivanir E, Jalanka J.   +8 more
europepmc   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health. [PDF]

J Intern Med
Maioli S, Nalvarte I, Ankarcrona M, Schultzberg M, Zuloaga KL, Goikolea J, Visser PJ, De Strooper B, Winblad B, Pizzo P, Williams PA, Rodriguez-Rodriguez P, Naia L.   +12 more
europepmc   +1 more source

Lipids: Emerging Players of Microglial Biology. [PDF]

Glia
Prakash P, Randolph CE, Walker KA, Chopra G.   +3 more
europepmc   +1 more source