Results 251 to 260 of about 31,210 (332)

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Comprehensive metabolomic/lipidomic characterization of patients with mitochondrial ATP synthase, short-chain acyl-CoA dehydrogenase and combined variant deficiencies. [PDF]

Heliyon
Dobešová D, Prídavok M, Brumarová R, Kvasnička A, Piskláková B, Ivanovová E, Brennerová K, Šaligová J, Potočňáková Ľ, Drobňaková S, Potočňáková J, Friedecký D.   +11 more
europepmc   +1 more source

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye, Yashi Shi, Alexander Mustea, Xiaodan Mao, Pengming Sun   +4 more
wiley   +1 more source

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics. [PDF]

Epilepsia
Vermeulen I, Mohren R, Neusinger M, Dancker TA, Vandenbosch M, Beckervordersandforth J, Balluff B, Van der Hel RP, Schijns OEMG, Hoogland G, Rijkers K, Cillero-Pastor B, ACE epilepsy surgery group.   +12 more
europepmc   +1 more source

Kidney Stone, Nutritional Perceptions and Impact of Tea on Stone Formation

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
ABSTRACT The significant financial burden that urinary stone disease places on healthcare systems is only anticipated to increase over time. It is becoming more common over the globe. It is an increasing urinary condition that impacts around 12% of the global population, and environmental variables appear to be a key contributor.
Munir Ahmed, Danish Kamal, Umber Mubeen, Sakhawat Riaz, Amber Tehseen, Muhammad Mazahir   +5 more
wiley   +1 more source

Advancing Clinical and Pathophysiological Insights into Pancreatitis Using Lipidomics and Metabolomics. [PDF]

Metabolites
Ahmed F, Zhao X, Setchell KDR, Abu-El-Haija M.   +3 more
europepmc   +1 more source

An edge β‐strand mutation turns ubiquitin into a pore‐forming amyloid

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Ubiquitin (Ub) is a highly conserved eukaryotic protein, generally regarded as stable and soluble under physiological conditions, playing a key role in maintaining cellular protein balance. Using complementary bioinformatic, biophysical, immunochemical, and electrophysiological approaches, we show that a single point mutation—the substitution ...
Daniela Meleleo, Rosanna Mallamaci, Vincenza Calò, Maurizio Losacco, Vincenzo Mangini, Fabio Arnesano   +5 more
wiley   +1 more source

Cell fusion in osteoclastogenesis. [PDF]

Biochem Soc Trans
Chernomordik LV, Melikov K.
europepmc   +1 more source

Third Generation Genome Sequencing of the Endobacterium Corynebacterium kroppenstedtii subsp. demodicis Reveals Details of Its Microbe‐Host‐Interaction With the Most Complex Human Commensal, Demodex folliculorum

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
The symbiotic interaction between Demodex folliculorum and Corynebacterium kroppenstedtii subsp. demodicis. Created by the author based on genomic and functional analyses presented in this work. The tripartite interaction between the human host, the mite Demodex folliculorum, and its endosymbiont Corynebacterium kroppenstedtii subsp. demodicis.
T. Steegmüller, S. Walch, S. Gschwendtner, A. Klingl, L. E. French, M. Flaig, B. M. Clanner‐Engelshofen   +6 more
wiley   +1 more source