Results 251 to 260 of about 8,775 (288)

Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway

Jianqin Yan, Zijian Zhao, Dengshuai Wei, Hongwei Zheng, Bin He, Yong Sun   +5 more
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Eicosapentaenoic Acid Triggers Phosphatidylserine Externalization in the Erythrocyte Membrane through Calcium Signaling and Anticholinesterase Activity. [PDF]

Physiol Res
Alharthy FH, Alsughayyir J, Alfhili MA.
europepmc   +1 more source

The molecular architecture of severe pediatric traumatic brain injury: integrated omics reveal therapeutic pathways. [PDF]

Crit Care
Hussain E, Prokop JW, Nonnemacher E, Ashrafi N, Yilmaz A, Mimi RA, Khalid A, Krinickis K, Lomeikaite V, Sanfilippo L, Maxton K, Charron J, Subrahmanya C, Goodyke A, Needs A, Woldring DR, Bupp CP, Hartog N, Gordevicius J, Graham SF, Rajasekaran S.   +20 more
europepmc   +1 more source

Immune cell activation produces locally scrambled foci of plasma membrane lipids. [PDF]

Faraday Discuss
Sputay D, Doktorova M, Chan SH, Guo EH, Wang HY, Lorent JH, Levental I, Levental KR.   +7 more
europepmc   +1 more source

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Phosphatidylserine-mediated oral tolerance

Cellular Immunology, 2023
Phosphatidylserine (PS) is an anionic phospholipid exposed on the surface of apoptotic cells. The exposure of PS typically recruits and signals phagocytes to engulf and silently clear these dying cells to maintain tolerance via immunological ignorance.
Nhan H, Nguyen, Vincent, Chak, Katherine, Keller, Helen, Wu, Sathy V, Balu-Iyer   +4 more
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Phosphatidylserine in Diabetes Research

Molecular Pharmaceutics, 2022
Phospholipids are lipids that constitute the basic structure of cell membranes. In-depth research has shown that in addition to supporting cell structures, phospholipids participate in multiple cellular processes, including promoting cell signal transduction, guiding protein translocation, activating enzymatic activity, and eliminating dysfunctional ...
Dandan Xiao, Wenguang Chang
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Preparation of Phosphatidylserine

Nature, 1963
SEVERAL methods for the preparation1,2 or quantitative isolation3 of phosphatidylserine are now in existence. An investigation of some of the factors involved in the chromatography of phospholipids4,5 revealed the role of H+ ion exchange in the conversion of the salt form to the acidic form of phosphatidylserine on a silicic acid column.
L, RATHBONE, P M, MARONEY
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Phosphatidylserine decarboxylase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes. The cloned bacterial gene encodes an integral membrane protein that is first made as a proenzyme, and subsequently proteolyzed to an alpha subunit, containing a pyruvoyl prosthetic group, and a beta subunit. Two
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Exploiting Surface Phosphatidylserine

Science, 2008
Many animals use the presence of the phospholipid phosphatidylserine (PS), on the outer leaflet of the plasma membrane, as a way to recognize and destroy apoptotic cells by phagocytic engulfment. In this issue, two papers illustrate the differential roles played by PS in normal cells and during virus infection (see the Perspective by Fairn
L. Bryan Ray, Stella M. Hurtley
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Phosphatidylserine synthase from yeast

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
Whereas mammalian cells produce PS by a base exchange reaction from preexisting phospholipids, yeast cells synthesize PS from CDP-diacylglycerol and serine by the PS synthase reaction. Yeast PS synthase was purified to homogeneity and shown to have a molecular mass of 23 kDa. The activity is dependent on either Mg2+ or Mn2+ and Triton X-100. The enzyme
S, Yamashita, J, Nikawa
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