Results 191 to 200 of about 32,452 (272)

ATP modulates holdase activity of fungal and human 110‐kilodalton heat shock proteins to promote protein folding

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract Heat shock proteins of the 70‐kDa family (Hsp70s) are highly abundant and conserved molecular chaperones that help preserve proteostasis primarily by facilitating proper protein folding. Heat shock protein of the 110‐kDa family (Hsp110s), a specialized branch of the Hsp70/Hsp110 superfamily, function both as nucleotide exchange factor (NEF ...
Justin M. Kidd   +6 more
wiley   +1 more source

Pd‐Catalyzed C─C Bond Borylation of Biphenylenes Leading to Tri‐Ortho‐Substituted Biaryls

open access: yesChemistry – A European Journal, Volume 32, Issue 16, 25 April 2026.
Palladium‐catalyzed ring‐opening C─C borylation of 1‐substituted biphenylenes yields a range of o,o,o′‐trisubstituted biaryls with two ortho‐boryl groups via selective cleavage of the least hindered C─C bond. The resulting diborylated products are readily amenable to sequential, site‐selective postfunctionalization.
Robyn V. Presland   +5 more
wiley   +1 more source

Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
The synthesis of a methylene‐linked acyldepsipeptide (ADEP) is reported. Success relied upon an improve method to generate a versatile vinyl glycine methyl ester synthon and a rationally optimized Grubb’s metathesis. NMR and in silico studies revealed an unusual trans–trans proline orientation for this new unnatural ADEP analog, advancing the ...
Katelyn G. Stevens-Davis   +6 more
wiley   +1 more source

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide-Cyclization-Bioconjugation. [PDF]

open access: yesAngew Chem Int Ed Engl
Stieger CE   +5 more
europepmc   +1 more source

Additives Promote Divergent Reactivity in Photolytic Deoxygenation and Lactonization Reactions of Cobalt Alkoxycarbonyls

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 14, 15 April 2026.
We report a carbonylation‐homolysis process to access acyl radicals that can undergo decarboxylation or cyclization onto tethered alkenes. In both cases, ligands and additives are shown to influence the outcome to give saturated or unsaturated products, in some cases with isomerization of the initial products.
Jacob N. Hackbarth   +4 more
wiley   +1 more source

Process-Ready Nickel-Catalyzed Suzuki-Miyaura Coupling Enabled by <i>tri</i>-ProPhos. [PDF]

open access: yesACS Catal
Yang J   +5 more
europepmc   +1 more source

The Binding of 3‐O‐Methylfluorescein Phosphate to the Catalytic Domain of the Human CDC25B Phosphatase: A Structural Investigation

open access: yesChemBioChem, Volume 27, Issue 7, 14 April 2026.
Structural studies on the complex that CDC25B C473S (CDC25B‐S) forms with the 3‐O‐methylfluorescein phosphate (3‐OMFP) reveal how the fluorogenic substrate binds CDC25B‐S, engaging key binding regions and inducing structural adjustments that stabilize the protein.
Romualdo Troisi   +5 more
wiley   +1 more source

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