Results 221 to 230 of about 51,028 (331)

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala   +4 more
wiley   +1 more source

Dialumene‐Mediated Production of Phosphines through P4 Reduction [PDF]

open access: bronze
Huihui Xu   +5 more
openalex   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

open access: yesBMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu   +12 more
wiley   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

open access: yesBiotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya   +7 more
wiley   +1 more source

Formation of a 14‐Electron Intermediate in Iridium Catalysis through Reductive Elimination: Dissociation Is Rate Determining

open access: yesChemistryEurope, EarlyView.
Dynamic NMR and trapping studies reveal that POCOP–Ir phenyl hydride complexes perform reductive coupling rapidly but dissociate benzene slowly. PCP–Ir analogs show comparatively slow reductive coupling and faster dissociation. This work experimentally clarifies aspects of C–H reductive elimination in iridium pincer complexes.(POCOP = bisphosphinite ...
Alice Spangenberg, Ola F. Wendt
wiley   +1 more source

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