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Phosphodiesterase Type 5 Inhibitors: Molecular Pharmacology and Interactions with other Phosphodiesterases

Current Pharmaceutical Design, 2005
Erectile function is determined by tight regulation of relaxation or contraction of corpus cavernosal smooth muscle, which is the result of a long and complex chain of molecular events. Control of erectile function resides in signaling pathways of the central and peripheral nervous system, as well as intracellular events in the penile smooth muscle ...
openaire   +3 more sources

Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease.

Journal of Medicinal Chemistry, 2018
Yinuo Wu   +4 more
semanticscholar   +1 more source

Cyclic Nucleotide Phosphodiesterases

2000
In multicellular organisms, cell functions are integrated through a large network of signals and homeostatic mechanisms that control the intracellular concentration of second messengers. This is a feature indispensable for the basal functions of the body, as well as for an efficient response to the continuous changes in the environment to which the ...
openaire   +2 more sources

Phosphodiesterase 4A

2007
Marco Conti   +2 more
openaire   +1 more source

PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.

Journal of Medicinal Chemistry, 2016
Chimed Jansen   +5 more
semanticscholar   +1 more source

Phosphodiesterase 1C

2007
Chen Yan, Joseph A. Beavo
openaire   +1 more source

Phosphodiesterase 7A

2007
Valeria Vasta, Joseph A. Beavo
openaire   +1 more source

Phosphodiesterase DosP increases persistence by reducing cAMP which reduces the signal indole

Biotechnology and Bioengineering, 2015
Brian W. Kwan   +4 more
semanticscholar   +1 more source

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

Nature Network Boston, 2005
E. Takimoto   +9 more
semanticscholar   +1 more source

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