Results 1 to 10 of about 133,740 (237)

A dose-ranging study of the inhaled dual phosphodiesterase 3 and 4 inhibitor ensifentrine in COPD [PDF]

Respiratory Research, 2020
Background Many patients with chronic obstructive pulmonary disease (COPD) still experience daily symptoms, exacerbations, and accelerated lung function decline, even when receiving maximal combined treatment with inhaled long-acting bronchodilators and ...
Dave Singh, Fernando J. Martinez, Henrik Watz, Thomas Bengtsson, Brian T. Maurer   +4 more
doaj   +2 more sources

Diastereomeric Specificity of 2',3'-Cyclic Nucleotide 3-Phosphodiesterase [PDF]

Nucleic Acids Research, 1996
The diastereomers of adenosine and uridine 2',3'-cyclic phosphorothioates were tested as substrates for 2',3'-cyclic nucleotide 3'-phosphodiesterase from bovine brain. The enzyme cleaves the Sp (or exo) diastereomers efficiently, whereas the Rp (or endo) diastereomers are resistant to hydrolysis, even after long incubation.
Paul A. Heaton, F. Eckstein
openalex   +4 more sources

3′:5′‐Cyclic Nucleotide Phosphodiesterases in Rat Tissues [PDF]

European Journal of Biochemistry, 1972
The rates of enzymatic hydrolysis of cyclic AMP, cyclic GMP, cyclic IMP, cyclic UMP, cyclic CMP and cyclic dTMP (all 3′:5′‐phosphates) have been assayed in several rat tissues. Subcellular distribution studies indicated that, in all tissues except brain and heart, most of the enzymatic activity is confined to the soluble cell fraction.The purine cyclic
Mary T. Campbell, Ivan T. Oliver
openalex   +5 more sources

PDE Inhibitors and Autophagy Regulators Modulate CRE-Dependent Luciferase Activity in Neuronal Cells from the Mouse Suprachiasmatic Nucleus [PDF]

Molecules
Background: Signaling pathways like those depending on cAMP/PKA, calcium/calmodulin/CaMK, MEK-1/MAPK or PI3K/Akt have been described to modulate suprachiasmatic nucleus (SCN) neuronal signaling via influencing transcription factors like CREB.
Erik Maronde, Abdelhaq Rami
doaj   +2 more sources

Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase [PDF]

Biochemical Journal, 1970
J. Bryan Smith, D. C. B. Mills
openalex   +4 more sources

Identification of a Glycerophosphocholine Phosphodiesterase, GDE5, in chicken [PDF]

E3S Web of Conferences, 2021
Glycerophosphodiester phosphodiesterase (GDPD/GDE) catalyzes the hydrolysis of glycerophosphodiesters to glycerol 3-phosphate and alcohol. It was discovered that the glycerophosphodiesterase family plays a role in lipid metabolism and signal pathway in ...
Gao Hao, Chang Pingan
doaj   +1 more source

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate

Frontiers in Physiology, 2022
Introduction: Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiovascular dysfunction, which could lead to shock. Current guidelines do not recommend any pharmacological treatment at core temperatures below 30°C, due ...
Adrina Kalasho Kuzmiszyn, Adrina Kalasho Kuzmiszyn, Adrina Kalasho Kuzmiszyn, Anders Lund Selli, Natalia Smaglyukova, Timofei Kondratiev, Ole-Martin Fuskevåg, Roy Andre Lyså, Aina Westrheim Ravna, Torkjel Tveita, Torkjel Tveita, Georg Sager, Erik Sveberg Dietrichs, Erik Sveberg Dietrichs   +13 more
doaj   +1 more source

Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes [PDF]

Hormone and Metabolic Research, 2012
The superfamily of cyclic nucleotide phosphodiesterases is comprised of 11 gene families. By hydrolyzing cAMP and cGMP, PDEs are major determinants in the regulation of intracellular concentrations of cyclic nucleotides and cyclic nucleotide-dependent signaling pathways. Two PDE3 subfamilies, PDE3A and PDE3B, have been described.
Vincent C. Manganiello, Faiyaz Ahmad, Eva Degerman   +2 more
openaire   +3 more sources

Phosphodiesterase 3 inhibition and cough in elderly asthmatics [PDF]

Cough, 2005
AbstractAimsCough is a common symptom of bronchial asthma, a chronic inflammatory airway disease. Recently, the therapeutic effects of selective phosphodiesterase (PDE) inhibitors have been focused on bronchial asthma. This study was designed to investigate the clinical effect of PDE 3 inhibition on cough reflex sensitivity in elderly patients with ...
Miki Abo, Shigeharu Myou, Masaki Fujimura, Hiroyuki Nakamura, Yoshihisa Ishiura, Takayoshi Oribe, Kouichi Nobata   +6 more
openaire   +3 more sources

Bacterial cyclic AMP-phosphodiesterase activity coordinates biofilm formation. [PDF]

PLoS ONE, 2013
Biofilm-related infections are a major contributor to human disease, and the capacity for surface attachment and biofilm formation are key attributes for the pathogenesis of microbes. Serratia marcescens type I fimbriae-dependent biofilms are coordinated
Eric J Kalivoda, Kimberly M Brothers, Nicholas A Stella, Matthew J Schmitt, Robert M Q Shanks   +4 more
doaj   +1 more source