Results 131 to 140 of about 16,465,333 (371)
Exploration, EarlyView.The engineered bacteria (2'3'‐cGAMP@E.coli) is designed to synthesize intracellular 2'3'‐cGAMP, enabling the assembly of personalized nanovaccines (nECTs) through a bioconjugation with autologous tumor antigens, circumventing elaborate chemical production processes. The therapeutic impact of nECTs is significantly amplified when combined with a fasting‐
Wenping Huang +7 more
wiley +1 more source
Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
British Journal of Pharmacology, EarlyView., 2023 Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley +1 more source
Journal of Lipid Research, 1973 The present study was undertaken to determine the relationship between the antilipolytic and lipolytic effects of insulin on hormone-stimulated lipolysis and the mechanisms of these reactions.
K.S. Desai, K.C. Li, A. Angel
doaj +1 more source
Effects of prematuration culture with a phosphodiesterase-3 inhibitor on oocyte morphology and embryo quality in in vitro maturation. [PDF]
Clin Exp Reprod Med, 2021 Cheruveetil MA +4 more
europepmc +1 more source
Identification of 2':3'-cyclic nucleotide 3'-phosphodiesterase in the vertebrate retina.
Journal of Biological Chemistry, 1980 The enzyme, 2':3'-cyclic nucleotide 3'-phosphodiesterase (2':3'-cNMP-3'-ase) has been used as a marker in the nervous system for the presence of myelin membrane or myelin-producing glial cells. In this study, goldfish and bovine neural retinas are found to have high levels of such a diesterase activity.
D Giulian, Stanford Moore
openaire +3 more sources
The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer
International Journal of Cancer, EarlyView.Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley +1 more source
Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond. [PDF]
Int J Mol Sci, 2021 Vinogradova TM, Lakatta EG.
europepmc +1 more source
Interdisciplinary Medicine, EarlyView.Background: Mitochondrial fission protein (FIS1), affecting energy metabolism and homeostasis, is crucial for mitochondrial quality control (MQC) and tumor progression. Key Points: It varies in expression across TME, influencing tumor progression.
Chao Wei +7 more
wiley +1 more source
An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase [PDF]
, 1970 Ernest G. Loten, J. G. T. Sneyd
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Phosphodiesterase 3 A expression in gastrointestinal stromal tumors
Virchows ArchivAbstract Phosphodiesterase 3A (PDE3A) is an emerging therapy target in various cancers with high expression, as in the majority of gastrointestinal stromal tumors (GISTs). However, its association with clinicopathological factors and patient survival in GISTs remains unexplored.
Harri Sihto +6 more
openaire +2 more sources