Results 151 to 160 of about 16,465,333 (371)

Genital Psoriasis: Shining Light on This Hidden Disease

JEADV Clinical Practice, EarlyView.
Psoriasis occurring on skin of the genital and perigenital regions has specific diagnostic and treatment requirements due to the sensitivity and private nature of these areas. A multidisciplinary group of experts in the management of genital psoriasis, the Genital Psoriasis Wellness Consortium, convened to discuss the impact of genital psoriasis on ...
Jennifer Cather, Melodie Young, Muriel Boreham, Shehla Admani, Tina Bhutani, Erin Foster, Richard Fried, Melinda Gooderham, Jeannette Jakus, Sandra Johnson, Ryoichi Kamide, John Koo, Tiffany Mayo, Michael Payette, Caitriona Ryan, Lucinda Whitney, Krista Bohnert, Melissa Seal, Patrick Burnett, Diane Hanna   +19 more
wiley   +1 more source

Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors. [PDF]

, 1982
We have measured the levels of 3',5'-guanosine monophosphate (cyclic GMP) in isolated retinas from toad to investigate their correlation to the opening and closing of the light-dependent permeability of photoreceptors. When Ca2+-induced changes in cyclic
Fain, GL, Woodruff, ML
core  

Efficacy of Apremilast in Refractory Genital Psoriasis: A Retrospective Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Genital pustular psoriasis is a rare and often underdiagnosed condition that can severely affect physical comfort, quality of life and psychological well‐being. It can be particularly challenging to manage, often requiring systemic therapies due to its potential unresponsiveness to conventional topical treatment.
Jonathan Krygier, Ursula Sass, Bertrand Richert   +2 more
wiley   +1 more source

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are intracellular mediators of innate immune responses to cytosolic pathogen-derived and host DNA.
Akshay Rohilla, Alok Kumar Singh, Benjamin Koleske, Geetha Srikrishna, William R. Bishai   +4 more
doaj   +1 more source

Cyclic 3', 5'-adenosine monophosphate phosphodiesterase mutants of Salmonella typhimurium [PDF]

, 1975
Meltem Alper, B N Ames
openalex   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder

Movement Disorders, EarlyView.
ABSTRACT Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document the first case of CMMs spontaneously occurring in Weimaraner dogs and to identify the underlying genetic ...
Cleo Schwarz, Florian Bartenschlager, Olivia Kershaw, Judith Braun, Julien Guevar, Vidhya Jagannathan, Jörg T. Epplen, Wencke Reineking, Wolfgang Baumgärtner, Kailash P. Bhatia, Achim D. Gruber, Tosso Leeb   +11 more
wiley   +1 more source

A New Cyclic Phosphodiesterase Having a 3'-Nucleotidase Activity from Escherichia coli B

, 1964
Yasuhiro Anraku
openalex   +1 more source

Early‐Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B

Movement Disorders, EarlyView.
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg, Noam Hadar, Eyal Kristal, Nicola Y. Roberts, Vadim Dolgin, Ilana Aminov, Amit Safran, Nadav Agam, Matan Jean, Ofek Freund, Eamonn G. Sheridan, James A. Poulter, Michelle L. Thompson, Yusra Algoos, Salma Al‐Qahtani, Lama AlAbdi, Sateesh Maddirevula, Verity Hartill, Henry Houlden, Reza Maroofian, Amit Nahum, Ohad S. Birk   +21 more
wiley   +1 more source

Activity of 3′, 5′-AMP phosphodiesterase in liver and adipose tissue of normal and diabetic rats

, 1968
B. Müller‐Oerlinghausen, U. Schwabe, A. Hasselblatt, F. H. Schmidt   +3 more
openalex   +1 more source