Results 151 to 160 of about 16,748,637 (363)

Could cilostazol be beneficial in COVID-19 treatment? Thinking about phosphodiesterase-3 as a therapeutic target. [PDF]

Int Immunopharmacol, 2021
Motta NAV, Autran LJ, Brazão SC, Lopes RO, Scaramello CBV, Lima GF, Brito FCF.   +6 more
europepmc   +1 more source

217. Long-Term 52-Week Results of Palace 1, A Phase 3, Randomized, Controlled Trial of Apremilast, an Oral Phosphodiesterase Inhibitor, In atients with Psoriatic Arthritis [PDF]

, 2014
Adewale Adebajo, Arthur Kavanaugh, Philip J. Mease, J. Wollenhaupt, ChiaChi Hu, K. Shah, Randall M. Stevens, Juan J. Gómez‐Reino   +7 more
openalex   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are intracellular mediators of innate immune responses to cytosolic pathogen-derived and host DNA.
Akshay Rohilla, Alok Kumar Singh, Benjamin Koleske, Geetha Srikrishna, William R. Bishai   +4 more
doaj   +1 more source

Interaction of caspase‐3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1) [PDF]

, 2003
Mhairi J. Frame, Rothwelle J. Tate, David R. Adams, Keith M. Morgan, Miles D. Houslay, Peter Vandenabeele, Nigel J. Pyne   +6 more
openalex   +1 more source

Erectile and ejaculatory outcomes after holmium laser enucleation of the prostate: A comprehensive narrative review

UroPrecision, EarlyView.
ABSTRACT Holmium laser enucleation of the prostate (HoLEP) has emerged as a widely adopted surgical technique for the management of benign prostatic hyperplasia (BPH), regardless of prostate size; however, its impact on male sexual function—particularly in terms of erectile and ejaculatory outcomes—remains a subject of ongoing debate.
Muhammed Arif İbiş, Fabio Castiglione, Nawal Khan, Ömer Onur Çakır, Zafer Tokatlı, Önder Yaman   +5 more
wiley   +1 more source

Administration of Cilostazol Prior to Intravenous Alteplase for Acute Branch Atheromatous Disease: A Report of Three Cases

Case Reports in Neurological Medicine
Patients with acute branch atheromatous disease often experience early neurological deterioration (END) in the first 24-h period, even after intravenous alteplase. Three cases treated with cilostazol, a phosphodiesterase 3-inhibitor, prior to intravenous
Eijirou Tanaka, Yoshinari Nagakane, Daiki Fukunaga, Daisuke Nakashima, Takehiro Yamada   +4 more
doaj   +1 more source

Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking [PDF]

, 2016
Roy S. Song, Rosa E. Tolentino, Eric A. Sobie, Susana R. Neves   +3 more
openalex   +1 more source

Penile traction therapy after radical pelvic surgery: Does it work?

UroPrecision, EarlyView.
Abstract Sexual dysfunction, including erectile dysfunction and penile shortening, is a frequent consequence of radical pelvic surgeries such as prostatectomy, cystoprostatectomy, and rectal cancer surgery. These complications primarily result from nerve injury and hypoxia‐induced corporal fibrosis.
Ahmet Tevfik Albayrak, Mustafa Faruk Usta   +1 more
wiley   +1 more source

Supersonic transporter (SST) deformity of penile prosthesis: Current management strategies

UroPrecision, EarlyView.
Abstract Supersonic transporter (SST) deformity, also known as floppy glans syndrome, represents a persistent source of post‐operative dissatisfaction among patients undergoing inflatable penile prosthesis (IPP) implantation. Although infection and mechanical failure rates have declined with advances in device design and surgical technique, SST ...
Mohammed Mahdi, Thairo A. Pereira, Muhammed A. M. Hammad   +2 more
wiley   +1 more source