Results 161 to 170 of about 16,748,637 (363)

214. Efficacy of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Physical Function and Pain in Patients with Psoriatic Arthritis and Current Skin Involvement: Results of Palace 3, a Phase 3, Randomized, Controlled Trial [PDF]

, 2014
Christopher J. Edwards, Francisco J. Blanco, Jeffrey Crowley, ChiaChi Hu, Randall M. Stevens, C. Birbara   +5 more
openalex   +1 more source

Penile rehabilitation in men after radical robotic prostatectomy: Fact or fiction?

UroPrecision, EarlyView.
Abstract Erectile dysfunction (ED) is one of the most frequent and distressing complications after radical prostatectomy (RP), significantly impairing patients’ quality of life and intimate relationships. Penile rehabilitation (PR) aims to preserve erectile tissue integrity, prevent fibrosis, and facilitate early functional recovery by restoring ...
Karen Zhang, Arnold P. P. Achermann, Hunter Hasley, Richard Bennett, Andrew Guo, Mohammed Mahdi, Lucas G. C. R. de Amorim, Helen L. Bernie, Thairo A. Pereira   +8 more
wiley   +1 more source

The Study of Chinese Herbal Medicinal Prescription with Enzyme Inhibitory Activity. VI. The Study of Makyo-kanseki-to with Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase

, 1992
Tamotsu NIKAIDO, Setsuko IIZUKA, Noriko OKADA, Takashi Kuge, Taichi OHMOTO   +4 more
openalex   +2 more sources

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Blunted cGMP response to agonists and enhanced glomerular cyclic 3′,5′-nucleotide phosphodiesterase activities in experimental congestive heart failure

, 1996
Thanom Supaporn, Sharon M. Sandberg, Daniel D. Borgeson, D. M. Heublein, Andreas Luchner, Chiming Wei, Thomas P. Douša, J. C. Burnett   +7 more
openalex   +1 more source

Molecular Modeling of 3-(1,3-Dioxoisoindolin-2-yl)benzyl Nitrate and its Molecular Docking Study with Phosphodiesterase-5 (PDE5) [PDF]

, 2019
Mehdi Nabati, Vida Bodaghi-Namileh
openalex   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors [PDF]

, 2019
Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, Chuan Wang, Longyuan Wang, Guoping Wang   +5 more
openalex   +1 more source

Treatment Satisfaction, Efficacy, and Safety of Delgocitinib Ointment Following Switch From Topical Corticosteroids for Trunk and Extremity Rash in Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent remissions and relapses. Topical anti‐inflammatory steroids are commonly used for treatment, but their long‐term use poses concerns because of potential side effects. Delgocitinib ointment, a Janus kinase inhibitor, has demonstrated efficacy in several clinical
Masatoshi Abe, Atsuyuki Igarashi, Hiroyuki Kitajima, Hiroyuki Toyama, Kenji Kabashima, Hidehisa Saeki   +5 more
wiley   +1 more source

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate‐protein kinase G signaling in diabetic mice

Journal of Diabetes Investigation
Aims/Introduction Diabetic cardiomyopathy (DCM) is a prevalent condition among individuals with diabetes, and is associated with a high mortality rate.
Shengping Lei, Xin Lu, Lei Yan, Tian Liu, Yan Niu, Jun Yu   +5 more
doaj   +1 more source