Results 171 to 180 of about 16,465,333 (371)

Comparison of in vivo and in vitro properties of cyclic adenosine 3':5'-monophosphate phosphodiesterase of amphibian oocytes.

, 1977
Catherine C. Allende, R Bravo, Jorge E. Allende   +2 more
openalex   +1 more source

Treatment Satisfaction, Efficacy, and Safety of Delgocitinib Ointment Following Switch From Topical Corticosteroids for Trunk and Extremity Rash in Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent remissions and relapses. Topical anti‐inflammatory steroids are commonly used for treatment, but their long‐term use poses concerns because of potential side effects. Delgocitinib ointment, a Janus kinase inhibitor, has demonstrated efficacy in several clinical
Masatoshi Abe, Atsuyuki Igarashi, Hiroyuki Kitajima, Hiroyuki Toyama, Kenji Kabashima, Hidehisa Saeki   +5 more
wiley   +1 more source

Guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities and cyclic guanosine 3':5'-monophosphate levels in normal and transformed fibroblasts in culture.

, 1976
John A. Nesbitt, W. B. Anderson, Zelma Baker Miller, Ira Pastan, Tom R. Russell, D Gospodarowicz   +5 more
openalex   +1 more source

A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults

Aging Cell, EarlyView.
We derived a 25‐protein blood‐based frailty signature (proteomic frailty index, pFI) predictive of the cumulative frailty index. The pFI was validated across independent cohorts and was significantly associated with physical, clinical, and cognitive function, as well as incident mortality and dementia, highlighting its potential as a biomarker of ...
Sanish Sathyan, Fangyu Liu, Toshiko Tanaka, Luigi Ferrucci, Emmeline Ayers, B. Gwen Windham, Tina Gao, Erica F. Weiss, Julián Candia, Josef Coresh, Nir Barzilai, Sofiya Milman, Keenan A. Walker, Joe Verghese   +13 more
wiley   +1 more source

K-134, a phosphodiesterase 3 inhibitor, reduces vascular inflammation and hypoxia, and prevents rupture of experimental abdominal aortic aneurysms. [PDF]

JVS Vasc Sci, 2020
Unno N, Tanaka H, Yata T, Kayama T, Yamanaka Y, Tsuyuki H, Sano M, Inuzuka K, Naruse E, Takeuchi H.   +9 more
europepmc   +1 more source

Mechanism of Activation of a Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase from Bovine Heart by Calcium Ions

, 1973
Tian Seng Teo, Jerry H. Wang
openalex   +1 more source

Paradoxical stimulation by 1‐methyl‐3‐isobutylxanthine of rat liver cyclic AMP phosphodiesterase activity [PDF]

, 1982
Christophé Erneux, Françoise Miot, Jean‐Marie Boeynaems, Jacques E. Dumont   +3 more
openalex   +1 more source

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2016
M. Turner, Elizabeth Matthes, A. Billet, Amy J. Ferguson, David Y. Thomas, S. Randell, L. Ostrowski, Kathy Abbott-Banner, J. Hanrahan   +8 more
semanticscholar   +1 more source

Management Strategies for Generalised Granuloma Annulare: A Systematic Review of Current and Emerging Therapies

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Generalised Granuloma Annulare (GGA) is a chronic inflammatory skin disorder with no standard treatment. Since the last review in 2013, new treatments and varied responses have highlighted the need for an updated synthesis to guide clinical decisions.
Luca Bettolini, Vincenzo Maione, Andrea Carugno, Giorgio Stabile, Antonio Podo Brunetti, Zeno Fratton, Enzo Errichetti, Nicola Zerbinati, Franco Rongioletti, Piergiacomo Calzavara‐Pinton, Mariateresa Rossi, Stefano Bighetti   +11 more
wiley   +1 more source

Double-blind, randomized, placebo-controlled pilot study of the phosphodiesterase-3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder.

CNS Neurosci Ther, 2021
Abdallah MS, Ramadan AN, Omara-Reda H, Mansour NO, Elsokary MA, Elsawah HK, Zaki SA, Abo Mansour HE, Mosalam EM.   +8 more
europepmc   +1 more source