Results 11 to 20 of about 16,465,333 (371)

The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury

BMC Infectious Diseases, 2009
Background Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low levels of cAMP have been associated with renal injury.
Seo Jeong Wook, Kwon Kun Young, Choi Won-Il, Beagle John, Quinn Deborah A, Hales Charles A   +5 more
doaj   +2 more sources

Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. [PDF]

J Clin Invest, 2021
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been
Wu Q, Sun L, Hu X, Wang X, Xu F, Chen B, Liang X, Xia J, Wang P, Aibara D, Zhang S, Zeng G, Yun C, Yan Y, Zhu Y, Bustin M, Zhang S, Gonzalez FJ, Jiang C.   +18 more
europepmc   +2 more sources

The role of cilostazol, a phosphodiesterase 3 inhibitor, on oocyte maturation and subsequent pregnancy in mice. [PDF]

PLoS ONE, 2012
It is important to identify effective contraceptive drugs that cause minimal disruption to physiological processes. Phosphodiesterase 3 (PDE3) inhibitors suppress meiosis in oocytes by decreasing the level of cAMP and blocking the extrusion of the first ...
Min Li, Yang Yu, Jie Yan, Li-Ying Yan, Yue Zhao, Rong Li, Ping Liu, Aaron J Hsueh, Jie Qiao   +8 more
doaj   +2 more sources

Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition.

PLoS ONE, 2014
Hepatocellular carcinoma (HCC) is the fifth common malignancy worldwide and the third leading cause of cancer-related death. Targeted therapies for HCC are being extensively developed with the limited success of sorafinib.
Liping Sun, Haitian Quan, Chengying Xie, Lei Wang, Youhong Hu, Liguang Lou   +5 more
doaj   +2 more sources

The Role of Cilostazol, a Phosphodiesterase-3 Inhibitor, in the Development of Atherosclerosis and Vascular Biology: A Review with Meta-Analysis. [PDF]

Int J Mol Sci
Atherosclerotic cardiovascular disease (ASCVD) stands as the leading global cause of mortality. Addressing this vital and pervasive condition requires a multifaceted approach, in which antiplatelet intervention plays a pivotal role, together with ...
Sohn M, Lim S.
europepmc   +2 more sources

The short-term bronchodilator effects of the dual phosphodiesterase 3 and 4 inhibitor RPL554 in COPD. [PDF]

Eur Respir J, 2018
We investigated the short-term bronchodilator effects of RPL554 (an inhaled dual phosphodiesterase 3 and 4 inhibitor) combined with other bronchodilators in chronic obstructive pulmonary disease patients with reversibility (>150 mL to short-acting ...
Singh D, Abbott-Banner K, Bengtsson T, Newman K.   +3 more
europepmc   +2 more sources

Experimental assessment of the toxicity of a cardiac drug based on a phosphodiesterase-3 inhibitor and ethylmethylhydroxypyridine succinate

Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 2022
The study aimed to establish the parameters of chronic toxicity of the newly developed drug based on phosphodiesterase-3 inhibitor and ethylmethylhydroxypyridine succinate in experiments on laboratory animals. The analysis was performed on white sexually
I. S. Varkholiak, B. Gutyj, O. B. Zolototska, L. P. Goralskyi, I. Sokulskyi, V. Khalak, V. Parchenko, A. Shcherbatyy, T. Martyshuk, Z. Guta   +9 more
semanticscholar   +1 more source

Phosphodiesterase Inhibitors: Present and Future

Barcelona Respiratory Network Reviews, 2023
Phosphodiesterase (PDE) inhibitors act on specific phosphodiesterase enzymes (fundamentally 3, 4 and 5), which are characterized by their expression in different organs.
José L. Izquierdo-Alonso
doaj   +1 more source

2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition by Organometallic Vanadium Complexes: A Potential New Paradigm for Studying CNS Degeneration

Brain Sciences, 2021
The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely.
David C. Platt, Jonathan Rink, Kamaljit Braich, Craig C. McLauchlan, Marjorie A. Jones   +4 more
doaj   +1 more source

Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3. [PDF]

Oncol Rep, 2015
A recent study demonstrated that intracellular small/microRNAs are released from cells, and some of these extracellular RNAs are embedded in vesicles, such as ceramide-rich exosomes, on lipid-bilayer membranes.
Kubota S, Chiba M, Watanabe M, Sakamoto M, Watanabe N.   +4 more
europepmc   +2 more sources