Results 221 to 230 of about 16,748,637 (363)

Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase

Experimental biology and medicine, 2010
Madelyn S. Hanson, A. Stephenson, E. Bowles, R. Sprague   +3 more
semanticscholar   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

EFFECT OF 2-(4-BENZYL-PIPERIDINO)-1-(4-HYDROXYPHENYL)-1-PROPANOL ON ADENYLATE CYCLASE AND 3′,5′-CYCLIC AMP PHOSPHODIESTERASE IN VITRO

, 1976
Yoshiaki Yamashita, Masami Kawai, Kei HOTTA   +2 more
openalex   +1 more source

Crystal structure of the catalytic fragment of 2',3'-cyclic nucleotide 3'-phosphodiesterase from human brain [PDF]

, 2005
Yasumitsu Sakamoto, Nobutada Tanaka, Tomomi Ichimiya, T. Kurihara, Kohei Nakamura   +4 more
openalex   +1 more source

Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition.

Cardiovascular Research, 2010
E. Qvigstad, L. R. Moltzau, J. M. Aronsen, C. Nguyen, K. Hougen, I. Sjaastad, F. Levy, T. Skomedal, J. Osnes   +8 more
semanticscholar   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Glucocorticoid-induced CREB activation and myostatin expression in C2C12 myotubes involves phosphodiesterase-3/4 signaling. [PDF]

Biochem Biophys Res Commun, 2018
Xie Y, Perry BD, Espinoza D, Zhang P, Price SR.   +4 more
europepmc   +1 more source

Effect of platelet aggregation inhibitors on purified human platelet cyclic 3’:5’-nucleotide phosphodiesterase

, 1976
Tomiko Asano, Yasuo Ochiai, Hiroyoshi Hidaka   +2 more
openalex   +1 more source

Assessment of a new in vitro maturation system for mouse and human cumulus-enclosed oocytes: three-dimensional prematuration culture in the presence of a phosphodiesterase 3-inhibitor.

Human Reproduction, 2009
L. Vanhoutte, D. Nogueira, F. Dumortier, P. D. Sutter   +3 more
semanticscholar   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source