Results 241 to 250 of about 16,465,333 (371)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Improved cytochemical method for cyclic 3',5'-nucleotide phosphodiesterase in rat rod outer segments.

, 1992
Toshihiro Takizawa, Takuma Saito
openalex   +2 more sources

Identification of Essential Residues in 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase [PDF]

, 2001
J. Jack Lee, Michel Gravel, Enoch Gao, Ryan C. O'Neill, Peter E. Braun   +4 more
openalex   +1 more source

cGAS–STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production

Cancer Science, EarlyView.
This study investigates the role of STING in photodynamic therapy (PDT) using talaporfin sodium. STING knockout reduced ROS generation and therapeutic efficacy, while combining a STING agonist with PDT enhanced antitumor effects. These findings suggest that STING regulates ROS homeostasis and can potentiate PDT outcomes.
Makiko Sasaki, Mamoru Tanaka, Yasunari Sasaki, Yuki Kojima, Taketo Suzuki, Hirotada Nishie, Shigeki Fukusada, Naomi Sugimura, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Hiromi Kataoka   +11 more
wiley   +1 more source

Anti-photoaging properties of the phosphodiesterase 3 inhibitor cilostazol in ultraviolet B-irradiated hairless mice. [PDF]

Sci Rep, 2016
Kim HN, Gil CH, Kim YR, Shin HK, Choi BT.   +4 more
europepmc   +1 more source

The Study of Chinese Herbal Medicinal Prescription with Enzyme Inhibitory Activity. V. The Study of Hange-shashin-to, Kanzo-shashin-to, Shokyo-shashin-to with Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase

, 1991
Misato Suzuki, T Nikaido, Taichi Ohmoto
openalex   +2 more sources

New Topical and Systemic Treatments for Atopic Dermatitis

Clinical &Experimental Allergy, EarlyView.
This review summarises new topical and systemic treatments for atopic dermatitis, their relative effectiveness, and important safety data. ABSTRACT Atopic dermatitis is an inflammatory skin condition characterised by pruritus and a chronic relapsing–remitting course.
Sara Mirali, Aaron M. Drucker
wiley   +1 more source

Interleukin-1β Induces Phosphodiesterase 4B2 Expression in Human Myometrial Cells through a Prostaglandin E₂- and Cyclic Adenosine 3′,5′-Monophosphate-Dependent Pathway [PDF]

, 2002
S. Oger, Céline Méhats, Emmanuelle Dallot, Françoise Ferré, Marie-Josèphe Leroy   +4 more
openalex   +1 more source

Nuclear and cytoplasmic maturation of in vitro matured human oocytes after temporary nuclear arrest by phosphodiesterase 3-inhibitor.

Human Reproduction, 2007
L. Vanhoutte, P. De Sutter, D. Nogueira, J. Gerris, M. Dhont, J. Van der Elst   +5 more
semanticscholar   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source