Results 271 to 280 of about 16,748,637 (363)

The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.

Blood, 2001
H. Bühring, Martina Seiffert, Christina Giesert, A. Marxer, Lothar Kanz, P. Valent, Kimihiko Sano   +6 more
semanticscholar   +1 more source

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

Experimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber, Kiana M. Schulze, Andrew G. Horn, Tyler E. McCoach, Zachary J. White, K. Sue Hageman, Stephanie E. Hall, Peter Sandner, Brad J. Behnke, Timothy I. Musch, David C. Poole   +10 more
wiley   +1 more source

Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience

Experimental Physiology, EarlyView.
Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings, Christopher P. Denton, Luigi Venetucci, Andrew W. Trafford   +3 more
wiley   +1 more source

Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening

, 2012
Yasuhiro Ichikawa, Utako Yokoyama, Mari Iwamoto, Jin Oshikawa, Satoshi Okumura, Motohiko Sato, Shumpei Yokota, Munetaka Masuda, Toshihide Asou, Yoshihiro Ishikawa   +9 more
openalex   +2 more sources

Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy. [PDF]

In Vivo
Mehanna OM, Elesawy BH, Elaskary A, Hassan MGM, Ahmed WMS, El Monsef ASA, Abbas MAM, Hammad AM, Elgazzar UB, Gabr NM, El-Sharnouby M, Sharahili AI, Khalifa MM.   +12 more
europepmc   +1 more source

2’,3’-Cyclic Nucleotide 3’-Phosphodiesterases Inhibit Hepatitis B Virus Replication

, 2013
Hui Ma, Xingliang Zhao, Xueyan Wang, Xingwang Xie, Jin‐Chao Han, Wenli Guan, Qin Wang, Lin Zhu, Xiao‐Ben Pan, Lai Wei   +9 more
openalex   +2 more sources

[Systemic sclerosis : A disease with multiple faces]. [PDF]

Dermatologie (Heidelb)
Evers C, Distler J, Distler O.
europepmc   +2 more sources

Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast. [PDF]

SAGE Open Med Case Rep
Barnawi G, Bobica AC, BinJadeed H, Ghazal S, Netchiporouk E.   +4 more
europepmc   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Covalent Binding of the Boronic Acid-Based Inhibitor GSK4394835A to Phosphodiesterase 3B, a Drug Target for Cardiovascular Disease. [PDF]

J Med Chem
Eaton SA, Christianson DW.
europepmc   +1 more source