Results 271 to 280 of about 16,465,333 (371)

Efficacy and safety of ME3183, an oral phosphodiesterase 4 inhibitor, in patients with plaque psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
We assessed four different doses of ME3183, a novel phosphodiesterase 4 inhibitor, and placebo in 132 patients with moderate to severe plaque psoriasis. At Week 16, more patients receiving ME3183 achieved ≥75% reduction in baseline Psoriasis Area and Severity Index scores than those receiving placebo, with no new safety concerns.
Kim A. Papp, April W. Armstrong, Tomokazu Koresawa, Kazunari Otake, Masayuki Hirata, Akiko Kano   +5 more
wiley   +1 more source

The long‐term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and Angiostrongylus vasorum infestation

Journal of Small Animal Practice, EarlyView.
Objectives Angiostrongylus vasorum (AV) is a metastrongylid parasite that has been associated with pulmonary hypertension (PH) in dogs. The objectives of the study were to describe the clinical presentation of dogs with AV and PH, document changes in tricuspid regurgitation maximum pressure gradient (TR Max PG) in subsequent months and years, record ...
R. Turner, D. Connolly, D. Brodbelt, S. Cortellini   +3 more
wiley   +1 more source

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer. [PDF]

Elife
Zhang C, Zhang Z, Wu Y, Wu Y, Cheng J, Luo K, Li Z, Zhang M, Wang J, Zhang X, Li Y.   +10 more
europepmc   +1 more source

3′-Phosphodiesterase and 3′→5′ Exonuclease Activities of Yeast Apn2 Protein and Requirement of These Activities for Repair of Oxidative DNA Damage

, 2001
Ildikó Unk, Lajos Haracska, Satya Prakash, Louise Prakash   +3 more
openalex   +1 more source

Antiremodeling Effects of Iloprost and the Dual-Selective Phosphodiesterase 3/4 Inhibitor Tolafentrine in Chronic Experimental Pulmonary Hypertension

Circulation Research, 2004
R. Schermuly, Klaus-Peter Kreisselmeier, H. Ghofrani, Arun Samidurai, S. Pullamsetti, N. Weissmann, C. Schudt, L. Ermert, W. Seeger, F. Grimminger   +9 more
semanticscholar   +1 more source

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots Without Altering the Performance of Two Root Herbivores, Diabrotica virgifera and Diabrotica balteata

Plant, Cell &Environment, EarlyView.
ABSTRACT Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore assays, this study aimed at providing a holistic description of maize root responses to EPNs and to assess ...
Arletys M. Verdecia‐Mogena, Paul A. Himmighofen, Pierre Mateo, Keerthi Divakaran, Mirco Hecht, Rimjhim R. Choudhury, Christian Parisod, Christelle A. M. Robert   +7 more
wiley   +1 more source

Neuroprotective Effects of Phosphodiesterase Inhibitors on Sestrin-2 (SESN2) Expression and Autophagy in Alzheimer's Disease Model. [PDF]

Cureus
Faikoglu G, Saygisever-Faikoglu K, Ozbasak H, Ugur SA, Uskur T, Akkan AG, Kelicen-Ugur P, Ozyazgan S.   +7 more
europepmc   +1 more source

Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2–11 Years

Pediatric Dermatology, EarlyView.
ABSTRACT Two 4‐week, phase 2, open‐label, maximal usage pharmacokinetic (PK) and safety studies of once‐daily roflumilast cream 0.3% (a potent phosphodiesterase 4 inhibitor) were conducted in children aged 2–5 years and 6–11 years with psoriasis. Evidence of systemic exposure to roflumilast and its active N‐oxide metabolite was seen in most patients ...
Adelaide A. Hebert, Shireen V. Guide, Vlada Groysman, Mercedes E. Gonzalez, Daisy Blanco, Vivian Laquer, Melissa S. Seal, Archie Thurston, David Krupa, Scott Snyder, Patrick Burnett, David H. Chu, David R. Berk, Robert C. Higham   +13 more
wiley   +1 more source

Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation

Experimental Physiology, EarlyView.
Abstract Total sleep deprivation (TSD) alters local cold tolerance and could thus increase the risk of cold injury. We evaluated the impact of acute caffeine intake, the main countermeasure to TSD‐related deleterious effects, on local cold tolerance before and after TSD.
Baptiste de Lorgeril, Pierre‐Emmanuel Tardo‐Dino, Cyprien Bourrilhon, Michael Quiquempoix, Catherine Drogou, Lise Mateo, Mégane Erblang, Philippe Colin, Pascal Van Beers, Mounir Chennaoui, Danielle Gomez‐Merino, Fabien Sauvet   +11 more
wiley   +1 more source

Stimulation of 3′→5′ Exonuclease and 3′-Phosphodiesterase Activities of Yeast Apn2 by Proliferating Cell Nuclear Antigen

, 2002
Ildikó Unk, Lajos Haracska, Xavier V. Gomes, Peter Burgers, Louise Prakash, Satya Prakash   +5 more
openalex   +1 more source