Results 21 to 30 of about 16,465,333 (371)

Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation. [PDF]

PLoS ONE, 2012
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is a highly abundant membrane-associated enzyme in the myelin sheath of the vertebrate nervous system.
Matti Myllykoski, Arne Raasakka, Huijong Han, Petri Kursula   +3 more
doaj   +1 more source

CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE IN BRAIN [PDF]

Journal of Histochemistry & Cytochemistry, 1969
The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in the rabbit central nervous system has been studied with a quantitative micromethod. A wide range of values between various structures was observed, but correlations with cellular density, monoamine content or other enzymes were not apparent.
Robert E. Johnston, Bruce McL. Breckenridge   +1 more
openaire   +3 more sources

Synthesis, enzyme inhibition and anticancer investigation of unsymmetrical 1,3-disubstituted ureas [PDF]

Journal of the Serbian Chemical Society, 2014
In this research work seventeen urea derivatives, including five new derivatives N-mesityl-N'-(3-methylphenyl)urea (2), N-(3-methoxyphenyl)-N'-(3-methylphenyl)urea (4), N-mesityl-N'-(4-methylphenyl)urea (6), N-(1,3-benzothiazol-2-yl)-N'-(3 ...
Mustafa Sana, Perveen Shahnaz, Khan Ajmal   +2 more
doaj   +1 more source

The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]

, 1990
The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Alzheimer, Christian, Ameri, A., Sutor, Bernd, Ten Bruggencate, Gerrit   +3 more
core   +1 more source

A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool

Journal of Research in Pharmacy Practice, 2015
Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3',5'-adenosine monophosphate (cAMP), and cyclic-3',5'-guanosine monophosphate that are ...
Nahid Eskandari, Omid Mirmosayyeb, Gazaleh Bordbari, Reza Bastan, Zahra Yousefi, Alireza Andalib   +5 more
doaj   +1 more source

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction

BMC Research Notes, 2012
Background Topo-poisons can produce an enzyme-DNA complex linked by a 3'- or 5'-phosphotyrosyl covalent bond. 3'-phosphotyrosyl bonds can be repaired by tyrosyl DNA phosphodiesterase-1 (TDP1), an enzyme known for years, but a complementary human enzyme 5'
Adhikari Sanjay, Karmahapatra Soumendra K, Karve Tejaswita M, Bandyopadhyay Sanjona, Woodrick Jordan, Manthena Praveen V, Glasgow Eric, Byers Stephen, Saha Tapas, Uren Aykut   +9 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - Cilostazol

Indian Journal of Psychological Medicine, 2012
Background: Cyclic nucleotide Phosphodiesterases (PDEs) are ubiquitously distributed in mammalian tissues and play a major role in cell signaling by hydrolyzing cyclic Adenosine Monophosphate (cAMP) and cyclic Guanosine Monophosphate (cGMP).
Dipesh S Patel, Indermeet Singh Anand, Parloop A Bhatt   +2 more
doaj   +1 more source

Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System

Frontiers in Microbiology, 2022
Streptococcus suis and Streptococcus agalactiae evade the innate immune system of the infected host by mechanisms mediated by cell wall-anchored proteins: SntA and CdnP, respectively.
Alicia Cabezas, María Jesús Costas, José Canales, Rosa María Pinto, Joaquim Rui Rodrigues, João Meireles Ribeiro, José Carlos Cameselle   +6 more
doaj   +1 more source