Results 301 to 310 of about 16,465,333 (371)

A phase IIb single-center study to assess the efficacy of apremilast for the treatment of nummular eczema. [PDF]

J Dtsch Dermatol Ges
Böhner A, Seiringer P, Kleeberger V, Rogner D, Oesterlin C, Biedermann T, Eyerich K, Lauffer F.   +7 more
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, Volume 98, Issue 3, Page 448-470, September 2025.
[Color figure can be viewed at www.annalsofneurology.org] Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Genetically proxied inhibition of Phosphodiesterase-5 and cancer risks: A drug-target Mendelian randomization analysis. [PDF]

Sci Rep
Tang K, Li B, Wu X, Wang M.
europepmc   +1 more source

Glycoprotein Proteinase in Agkistrodon bilineatus Venom [PDF]

, 1980
Johnson, Bob D., Ruff, John D., Sifford, Dewey H.   +2 more
core   +2 more sources

What Does Iron Mean to an Oligodendrocyte?

Glia, Volume 73, Issue 9, Page 1784-1804, September 2025.
Main Points Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley   +1 more source

PDE9A Promotes Calcium-Handling Dysfunction in Right Heart Failure via cGMP-PKG Pathway Suppression: A Mechanistic and Therapeutic Review. [PDF]

Int J Mol Sci
Thatcher S, Khalid A, Ahmed AB, Gill R, Kia A.   +4 more
europepmc   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi, Sajjad Shafaeibajestan, Sevda Asadpour, Ghazal Alyari, Niloofar Taei, Moein Kohkalani, Ramin Raoufinia, Hamed Afarande, Ehsan Saburi   +8 more
wiley   +1 more source

The Missing Enzymes: A Call to Update Pharmacological Profiling Practices for Better Drug Safety Assessment. [PDF]

J Med Chem
Maciag M, Karamyan VT.
europepmc   +1 more source

Isolation of Phospholipase A2 from Agkistrodon bilineatus Venom [PDF]

, 1980
Johnson, Bob D., Landberg, Karl H., Sifford, Dewey H.   +2 more
core   +2 more sources

Chromosome‐level genome of Zoysia sinica in the intertidal zone reveals genomic insights into waterlogging stress adaptation

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract Zoysia sinica is a perennial grass that thrives in intertidal zones, even under extreme waterlogging stress. In this study, we present a high‐quality chromosome‐level genome assembly of Z. sinica, with a total size of 312.67 Mb. Through genome annotation, we identified 29,551 protein‐coding genes in the Z. sinica genome and re‐annotated 32,925,
Hyeonseon Park, Eunji Bae, Jae Gyeong Jung, Jaewook Kim, Bae Young Choi, Geungjoo Lee, Changsoo Kim, Donghwan Shim   +7 more
wiley   +1 more source