Results 321 to 330 of about 16,748,637 (363)

2′, 3′‐cyclic nucleotide 3′ ‐phosphodiesterase in cerebrospinal fluid

Neurology, 1981
The activity of the myelin-associated enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) was assayed in the cerebrospinal fluid (CSF) of 107 neurologic patients by a new and sensitive fluorometric method. The activity of CNP was about 20 nmol per hour per milligram protein or 12 nmol per hour per milliliter CSF.
I, Raes, S, Weissbarth, H S, Maker, G M, Lehrer   +3 more
openaire   +2 more sources

Phosphodiesterase-3 inhibitor (cilostazol) attenuates oxidative stress-induced mitochondrial dysfunction in the heart

Journal of Geriatric Cardiology, 2014
Background Cilostazol is a type 3 phosphodiesterase inhibitor which has been previously demonstrated to prevent the occurrence of tachyarrhythmia and improve defibrillation efficacy.
S. Chattipakorn, Savitree Thummasorn, J. Sanit, N. Chattipakorn   +3 more
semanticscholar   +1 more source

Phosphodiesterase 3 (PDE3): Structure, Localization and Function

Cardiovascular & Hematological Agents in Medicinal Chemistry, 2009
Cyclic adenosine 3'5'-monophosphate (cAMP) and cyclic guanosine 3'5'-monophosphate (cGMP) are critical intracellular messengers involved in transduction of signals generated by a wide variety of extracellular stimuli, including growth factors, cytokines, peptide hormones, light and neurotransmitters.
Taku, Murata, Kasumi, Shimizu, Kenichi, Hiramoto, Toshiro, Tagawa   +3 more
openaire   +2 more sources

Cyclic 3′,5′-AMP phosphodiesterase of Neurosporacrassa

Biochemical and Biophysical Research Communications, 1973
Abstract Cyclic 3′,5′-AMP (cAMP) phosphodiesterase activity can be demonstrated in extracts of Neurospora crassa . The activity is particulate, has a pH optimum of 7.4, and consists of two forms that have different cAMP binding constants. Methylxanthines, inorganic phosphate, and EDTA are inhibitors of the diesterase as are ATP, ADP, and 8 ...
W A, Scott, B, Solomon
openaire   +2 more sources

Biosynthesis of the Myelin 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterases

Journal of Neurochemistry, 1990
Abstract:We have investigated the site of synthesis of the 2′,3′‐cyclic nucleotide 3′‐phosphodiesterases (CNPs I and II) in rat brain. Rapid kinetics of incorporation of CNPs into oligodendrocyte plasma membrane in the intact brain are consistent with their synthesis on free polysomes.
C S, Gillespie, L, Bernier, P J, Brophy, D R, Colman   +3 more
openaire   +2 more sources

3-O-Methylquercetin More Selectively Inhibits Phosphodiesterase Subtype 3

Planta Medica, 2003
Rhamnus nakaharai Hayata (Rhamnaceae), has been used as a folk medicine in Taiwan for treating constipation, inflammation, tumors and asthma. 3-O-methylquercetin (3-MQ), a main constituent of the plant, has been reported to inhibit total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis.
Wun-Chang, Ko, Mei-Chun, Chen, Sheng-Hao, Wang, Ya-Hsin, Lai, Jun-Hao, Chen, Chun-Nan, Lin   +5 more
openaire   +2 more sources

2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase

1978
2′,3′-Cyclic nucleotide 3′-phosphodiesterase (CNPase, EC 3.1.4.37*) has been widely used for several years as a marker for the presence of myelin in the central nervous system, but no review is available on its application and limitation as a marker enzyme and there is no information on its role in myelin.
Neil Raymond Sims, Patrick Robert Carnegie   +1 more
openaire   +1 more source

Origin of brain 2′,3′-cyclic-nucleotide 3′-phosphodiesterase doublet

Neuroscience Letters, 1992
The present study established that 2',3'-cyclic-nucleotide 3'-phosphodiesterase doublet common to mammalian brain originates from an alternative splicing. Peptides specific to the predicted larger translation product were synthesized and antisera against these peptides were prepared.
T, Kurihara, Y, Tohyama, J, Yamamoto, T, Kanamatsu, R, Watanabe, S, Kitajima   +5 more
openaire   +2 more sources

Structure of mouse 2′,3′-cyclic-nucleotide 3′-phosphodiesterase gene

Biochemical and Biophysical Research Communications, 1989
The mouse 2',3'-cyclic-nucleotide 3'-phosphodiesterase gene was isolated from a mouse gene library. Restriction endonuclease mapping and DNA sequencing analysis revealed that this gene is about 6 kb long and is separated into three exons by two introns. The transcription initiation site was identified.
K, Monoh, T, Kurihara, K, Sakimura, Y, Takahashi   +3 more
openaire   +2 more sources

Structural and functional evolution of 2′,3′-cyclic nucleotide 3′-phosphodiesterase

Brain Research, 2016
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant membrane-associated enzyme within the vertebrate myelin sheath. While the physiological function of CNPase still remains to be characterized in detail, it is known - in addition to its in vitro enzymatic activity - to interact with other proteins, small molecules, and membrane ...
Matti, Myllykoski, Leonie, Seidel, Gopinath, Muruganandam, Arne, Raasakka, Andrew E, Torda, Petri, Kursula   +5 more
openaire   +2 more sources