Results 331 to 340 of about 16,748,637 (363)

Cyclic 3′, 5′-AMP phosphodiesterase of rabbit aorta

Biochimica et Biophysica Acta (BBA) - Enzymology, 1975
Cyclic AMP and cyclic GMP phosphodiesterase activities (3' : 5'-cyclic AMP 5'-nucleotidohydrolase, EC 3.1.4.17) were demonstrated in the isolated intima, media, and adventitia of rabbit aorta. The activity for cyclic AMP hydrolysis in the intima was 2.7-fold higher than that for cyclic GMP hydrolysis. The activity for cyclic AMP hydrolysis in the media
H, Hidaka, T, Asano, T, Shimamoto
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Quinazolines: Combined type 3 and 4 phosphodiesterase inhibitors

Bioorganic & Medicinal Chemistry Letters, 1998
A series of quinazolines has been prepared and evaluated for its ability to inhibit cyclic AMP phosphodiesterase type 3, type 4A, 4B and 4D. The most potent inhibitors showed IC50 values in the nanomolar range for type 3 and type 4 isoforms and bind with high affinity to the [3H]rolipram binding site. These quinazolines represent a new family of potent
B, Charpiot, J, Brun, I, Donze, R, Naef, M, Stefani, T, Mueller   +5 more
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Glucose-mediated Insulin Release: 3′,5′ cAMP Phosphodiesterase

Diabetes, 1973
Cyclic nucleotide phosphodiesterase from isolated mouse islets of Langerhans has been investigated and characterized. The enzyme has a pH optimum of 8.5 and is magnesium dependent, 10 mM. magnesium causing a fivefold increase in V max. Calcium is without effect on the enzyme. It is inhibited by theophylline and parachloromercuribenzoate.
V, Bowen, N R, Lazaus
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3′:5′-cyclic-nucleotide phosphodiesterases of mammalian sera

Biochimica et Biophysica Acta (BBA) - Enzymology, 1975
Cyclic AMP and cyclic GMP phosphodiesterases (3':5'-cyclic-nucleotide 5'-nucleotidohydrolase EC 3.1.4.17) were found in the sera of human, dog, rabbit and rat. The formed elements of blood were not present in sera and thus not the source of the phosphodiesterase.
T, Asano, H, Hidaka
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Dual expression and differential regulation of phosphodiesterase 3A and phosphodiesterase 3B in human vascular smooth muscle: implications for phosphodiesterase 3 inhibition in human cardiovascular tissues.

Molecular Pharmacology, 2000
Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes whose physiological role is the attenuation of the signaling mediated by the ubiquitous second messengers cAMP and cGMP.
D. Palmer, D. Maurice
semanticscholar   +1 more source

Cyclic 3′,5′-nucleotide phosphodiesterase of Serratia marcescens

Biochimica et Biophysica Acta (BBA) - Enzymology, 1970
Abstract 1. 1. A cyclic 3′,5′-nucleotide phosphodiesterase from the cells of Serratia marcescens was purified over 1000-fold. The purified preparation showed a pH maximum in the region of 7.5–8.5 in Tris-HCl buffer, with a K m of 0.52 mM for adenosine cyclic 3′,5′-phosphate.
T, Okabayashi, M, Ide
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Expression of phosphodiesterase 3 in rat submandibular gland

Archives of Oral Biology, 2000
The expression of phosphodiesterase (PDE) 3 isoforms was investigated in extracts of rat submandibular gland by reverse transcription-polymerase chain reaction (RT-PCR) and the PCR fragments were then sequenced. PDE3 activity was detected in gland homogenates; about 90% of the activity was in the supernatant fraction and about 10% in the particulate ...
T, Murata, T, Sugatani, T, Tagawa
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Imidazoquinazolinone based inhibitors of Phosphodiesterase 3

2017
Phosphodiesterases (PDE) catalyze the deactivation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibiting a cell’s PDE increases the level of cAMP or cGMP in the cytosol, enhancing the cells response to stimuli. Selectively inhibiting a PDE subtype can cause a specific cell or tissue type to elicit a therapeutic ...
openaire   +1 more source

Reproducibility of migraine-like attacks induced by phosphodiesterase-3-inhibitor cilostazol

Cephalalgia, 2018
Sabrina Khan, Marie Deen, A. Hougaard, F. Amin, M. Ashina   +4 more
semanticscholar   +1 more source

Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells

Journal of dentistry research, 2017
S. Miyauchi, J. Kitagaki, R. Masumoto, A. Imai, K. Kobayashi, A. Nakaya, S. Kawai, C. Fujihara, Y. Asano, M. Yamashita, M. Yanagita, S. Yamada, M. Kitamura, S. Murakami   +13 more
semanticscholar   +1 more source