Results 31 to 40 of about 16,465,333 (371)

Editorial [PDF]

, 2016
No abstract ...
Baillie, George S.
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Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

Cell Reports, 2022
Summary: Tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety and is implicated in the repair of trapped topoisomerase I (Top1)-DNA covalent complexes (Top1cc).
Sangheeta Bhattacharjee, Ishita Rehman, Saini Basu, Souvik Nandy, Julia M. Richardson, Benu Brata Das   +5 more
doaj   +1 more source

Modulation of the asymmetry of sea urchin sperm flagellar bending by calmodulin [PDF]

, 1985
Sea urchin spermatozoa demembranated with Triton X-100 in the presence of EGTA, termed potentially asymmetric, generate asymmetric bending waves in reactivation solutions containing EGTA. After they are converted to the potentially symmetric condition by
Brokaw, C. J., Nagayama, S. M.
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Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Bolger, G.B., Collins, D.M., Hill, E.V., Houslay, M.D., Klussmann, E., Mackie, S., Millar, J.K., Murdoch, H., Porteous, D.J.   +8 more
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Role of phosphodiesterase in glucagon resistance of large adipocytes

Journal of Lipid Research, 1974
The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter ≃ 45 μm) and large (mean diameter ≃ 78 μm ...
Richard A. De Santis, Tessa Gorenstein, James N. Livingston, Dean H. Lockwood   +3 more
doaj   +1 more source

The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase. [PDF]

PLoS ONE, 2016
Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon in Gram-negative bacteria, its identification was undertaken.
Iralis López-Villamizar, Alicia Cabezas, Rosa María Pinto, José Canales, João Meireles Ribeiro, José Carlos Cameselle, María Jesús Costas   +6 more
doaj   +1 more source

Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]

, 2017
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo, CECI GALANOS, Roberta, Crescioli, Clara, Di Luigi, Luigi, Duranti, Guglielmo, Sabatini, Stefania, Sansone, Andrea, Sansone, Massimiliano, Sgrò, Paolo   +8 more
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Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles

Clinics, 2011
OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester ...
Silvia Elaine Ferreira-Melo, Caroline Demacq, Silvia Lacchini, José Eduardo Krieger, Maria Cláudia Irigoyen, Heitor Moreno   +5 more
doaj   +1 more source

Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein

BMC Neuroscience, 2023
Background Studies of the molecular mechanisms of nerve regeneration have led to the discovery of several proteins that are induced during successful nerve regeneration.
Ashoka C. Bandla, Aditya S. Sheth, Sara M. Zarate, Suraj Uskamalla, Elizabeth C. Hager, Victor A. Villarreal, Maribel González-García, Rafael P. Ballestero   +7 more
doaj   +1 more source

Mutations in phosphodiesterase 6 identified in familial cases of retinitis pigmentosa. [PDF]

, 2016
To delineate the genetic determinants associated with retinitis pigmentosa (RP), a hereditary retinal disorder, we recruited four large families manifesting cardinal symptoms of RP. We localized these families to regions on the human genome harboring the
Akram, Javed, Ayyagari, Radha, Gottsch, Clare Brooks S, Guru, Aditya A, Kabir, Firoz, Khan, Shaheen N, Naeem, Muhammad Asif, Riazuddin, S Amer, Riazuddin, Sheikh, Ullah, Inayat   +9 more
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