Results 31 to 40 of about 16,748,637 (363)

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction

BMC Research Notes, 2012
Background Topo-poisons can produce an enzyme-DNA complex linked by a 3'- or 5'-phosphotyrosyl covalent bond. 3'-phosphotyrosyl bonds can be repaired by tyrosyl DNA phosphodiesterase-1 (TDP1), an enzyme known for years, but a complementary human enzyme 5'
Adhikari Sanjay, Karmahapatra Soumendra K, Karve Tejaswita M, Bandyopadhyay Sanjona, Woodrick Jordan, Manthena Praveen V, Glasgow Eric, Byers Stephen, Saha Tapas, Uren Aykut   +9 more
doaj   +1 more source

CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE IN BRAIN [PDF]

Journal of Histochemistry & Cytochemistry, 1969
The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in the rabbit central nervous system has been studied with a quantitative micromethod. A wide range of values between various structures was observed, but correlations with cellular density, monoamine content or other enzymes were not apparent.
B M, Breckenridge, R E, Johnston
openaire   +2 more sources

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - Cilostazol

Indian Journal of Psychological Medicine, 2012
Background: Cyclic nucleotide Phosphodiesterases (PDEs) are ubiquitously distributed in mammalian tissues and play a major role in cell signaling by hydrolyzing cyclic Adenosine Monophosphate (cAMP) and cyclic Guanosine Monophosphate (cGMP).
Dipesh S Patel, Indermeet Singh Anand, Parloop A Bhatt   +2 more
doaj   +1 more source

Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System

Frontiers in Microbiology, 2022
Streptococcus suis and Streptococcus agalactiae evade the innate immune system of the infected host by mechanisms mediated by cell wall-anchored proteins: SntA and CdnP, respectively.
Alicia Cabezas, María Jesús Costas, José Canales, Rosa María Pinto, Joaquim Rui Rodrigues, João Meireles Ribeiro, José Carlos Cameselle   +6 more
doaj   +1 more source

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]

, 2015
background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S., Bottcher, R., Dulla, K., Henderson, D. J. P., Hoffmann, R., Houslay, M. D., Jenster, G., Lehman, M. L., Merkle, D., Tevz, G., van Leenders, G. J. L. H., van Strijp, D., Waanders, L. F.   +12 more
core   +1 more source

Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

Cell Reports, 2022
Summary: Tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety and is implicated in the repair of trapped topoisomerase I (Top1)-DNA covalent complexes (Top1cc).
Sangheeta Bhattacharjee, Ishita Rehman, Saini Basu, Souvik Nandy, Julia M. Richardson, Benu Brata Das   +5 more
doaj   +1 more source

Is phosphodiesterase type 5 inhibitor use associated with condom breakage? [PDF]

, 2009
This is an open access article - Copyright © 2009 by the BMJ Publishing Group Ltd. All rights reserved.We tested the hypothesis that phosphodiesterase type 5 inhibitor (PDE5i) use would be associated with increased likelihood of condom breakage using an
Crosby, RA, Graham, CA, Sanders, SA, Yarber, WL   +3 more
core   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Role of phosphodiesterase in glucagon resistance of large adipocytes

Journal of Lipid Research, 1974
The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter ≃ 45 μm) and large (mean diameter ≃ 78 μm ...
Richard A. De Santis, Tessa Gorenstein, James N. Livingston, Dean H. Lockwood   +3 more
doaj   +1 more source