Results 41 to 50 of about 16,748,637 (363)

Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein

BMC Neuroscience, 2023
Background Studies of the molecular mechanisms of nerve regeneration have led to the discovery of several proteins that are induced during successful nerve regeneration.
Ashoka C. Bandla, Aditya S. Sheth, Sara M. Zarate, Suraj Uskamalla, Elizabeth C. Hager, Victor A. Villarreal, Maribel González-García, Rafael P. Ballestero   +7 more
doaj   +1 more source

Editorial [PDF]

, 2016
No abstract ...
Baillie, George S.
core   +1 more source

The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase. [PDF]

PLoS ONE, 2016
Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon in Gram-negative bacteria, its identification was undertaken.
Iralis López-Villamizar, Alicia Cabezas, Rosa María Pinto, José Canales, João Meireles Ribeiro, José Carlos Cameselle, María Jesús Costas   +6 more
doaj   +1 more source

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Bolger, G.B., Collins, D.M., Hill, E.V., Houslay, M.D., Klussmann, E., Mackie, S., Millar, J.K., Murdoch, H., Porteous, D.J.   +8 more
core   +1 more source

Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles

Clinics, 2011
OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester ...
Silvia Elaine Ferreira-Melo, Caroline Demacq, Silvia Lacchini, José Eduardo Krieger, Maria Cláudia Irigoyen, Heitor Moreno   +5 more
doaj   +1 more source

Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis [PDF]

, 2017
Background: Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/ cGMP), signal molecules in transduction pathways regulating crucial aspects of cell life.
Biagioni, Stefano, Cardarelli, Silvia, Giorgi, Mauro, Malatesta, Francesco, Naro, Fabio, Saliola, Michele   +5 more
core   +1 more source

Reduced Airway Hyperresponsiveness by Phosphodiesterase 3 and 4 Inhibitors in Guinea-Pigs

Mediators of Inflammation, 1999
The aim of the present study was to compare the effects of selective phosphodiesterase (PDE) 3, 4 and 5 inhibitors on antigen-induced airway hyperresponsiveness in sensitized guinea-pigs.
Nöella Germain, Elisabeth Boichot, Jean-Michel Planquois, Vincent Lagente   +3 more
doaj   +1 more source

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Journal of Medical Sciences, 2015
Background: Phosphodiesterase 4 (PDE4) inhibitors negatively modulate many inflammatory responses, and some of these pharmacological effects are mediated by inhibition of PDE4B in inflammatory cells.
Ciou-Rong Lai, Huan-Chu Lo, Yi-Ling Chen, Jing-Xing Yang, Shiau-Li Ding, Hsian-He Hsu, Marco Conti, Chin-Pyng Wu, S L Catherine Jin   +8 more
doaj   +3 more sources

Modulation of the asymmetry of sea urchin sperm flagellar bending by calmodulin [PDF]

, 1985
Sea urchin spermatozoa demembranated with Triton X-100 in the presence of EGTA, termed potentially asymmetric, generate asymmetric bending waves in reactivation solutions containing EGTA. After they are converted to the potentially symmetric condition by
Brokaw, C. J., Nagayama, S. M.
core   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source