Results 91 to 100 of about 102,229 (258)

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide

Frontiers in Neuroscience, 2019
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms, Frank S. Menniti, Christopher J. Schmidt   +2 more
doaj   +1 more source

The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Mice. [PDF]

Front Cell Infect Microbiol, 2022
Barbieri D, Gomez L, Royer L, Dupuy F, Franetich JF, Tefit M, N'Dri ME, Mazier D, Silvie O, Moreno-Sabater A, Lavazec C.   +10 more
europepmc   +1 more source

Cardiac Uses of Phosphodiesterase-5 Inhibitors

Journal of the American College of Cardiology, 2012
Phosphodiesterase-5 inhibitors (PDE5Is) improve erectile function by enhancing nitric oxide availability in the penis and its supplying vasculature, resulting in vasodilation and increased blood flow. PDE5Is might benefit cardiovascular diseases because phosphodiesterase-5 is also located elsewhere in the body, including the pulmonary and systemic ...
Bryan G. Schwartz, Gary Comstock, Vera J. Stecher, Robert A. Kloner, Robert A. Kloner, Laurence A. Levine   +5 more
openaire   +3 more sources

Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma

Frontiers in Cellular Neuroscience
IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran, Ning Hu, Catherine J. Kane, Steven H. Green   +3 more
doaj   +1 more source

The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor

Acta Pharmaceutica, 2015
PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated.
Suzuki Osamu, Goto Taiji, Yoshino Toshiharu, Nakamura Satoshi, Maeda Hiroaki   +4 more
doaj   +1 more source

Analyzing the Clinical Efficacy of a Type 5 Phosphodiesterase Inhibitor Combined With Ziyin Baihuo Granules in the Treatment of Erectile Dysfunction. [PDF]

Am J Mens Health, 2022
Wang R, Sun WG, Zhang TB, Zheng T, Lv KL, Nan YH, Zhang WX.   +6 more
europepmc   +1 more source

Effects of cyclic adenosine 3,5-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. [PDF]

, 1982
As a test of the hypothesis that cyclic nucleotides play a role in the regulation of retinomotor movements and disc shedding in the photoreceptor-pigment epithelial complex, we have used an in vitro eyecup preparation that sustains both disc shedding and
Besharse, J, BURNSIDE, Beth, Dunis, D
core   +1 more source

Perspectives on Ensifentrine and Its Therapeutic Potential in the Treatment of COPD: Evidence to Date

International Journal of COPD
Muhammad Asad Faruqi,1 Malik M Khurram S Khan,1 David M Mannino1,2 1University of Kentucky College of Medicine, Lexington, KY, USA; 2COPD Foundation, Miami, FL, USACorrespondence: David M Mannino, Department of Medicine, University of Kentucky College of
Faruqi MA, Khan MMKS, Mannino DM
doaj  

Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension

Vascular Health and Risk Management, 2008
Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S MacdonaldHeart Lung Transplant Unit, St Vincent’s Hospital, Sydney, New South Wales, AustraliaAbstract: Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE-5).
Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S Macdonald   +3 more
doaj  

The Adenylate Cyclase Activator Forskolin Potentiates the Positive Inotropic Effect of the Phosphodiesterase Inhibitor Milrinone But Not of the Calcium Sensitizer Levosimendan nor of Its Hemodynamically Active Metabolites: An Apparent Conundrum. [PDF]

J Cardiovasc Pharmacol, 2022
Levijoki J, Pollesello P, Pollesello P, Grossini E, Papp Z.   +4 more
europepmc   +1 more source