Results 91 to 100 of about 2,974,682 (398)
Advanced Science, EarlyView.The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan +20 more
wiley +1 more source
New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 [PDF]
, 2021 Oksana V. Salomatina +9 more
openalex +1 more source
Effect of the Phosphodiesterase Inhibitor Pentoxyfylline on Human Sperm Motility
Andrologia, 2009 Einfluß des Phosphodiesterase‐Inhibitors Pentoxyphyllin auf die Motilität menschlicher ...
N. Aparicio +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi +6 more
wiley +1 more source
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD
Drug Design, Development and Therapy, 2010 Mark A Giembycz1, Stephen K Field2Departments of 1Physiology and Pharmacology and 2Medicine, Airway Inflammation Research Group, Faculty of Medicine, University of Calgary, Alberta, CanadaAbstract: In April 2010, the European Medicines Agency Committee ...
Mark A Giembycz, Stephen K Field
doaj
PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS
International Journal of Clinical Practice, 2002 SUMMARYThe clinical properties (efficacy and safety profile) of a medicine are related not only to its mode of action, but also to its selectivity for its target (usually a receptor or enzyme) and are also influenced by its pharmacokinetic properties (absorption, distribution, metabolism and elimination).
J D, Corbin, S H, Francis
openaire +2 more sources
Advanced Science, EarlyView.Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng +20 more
wiley +1 more source
Surface Binding Energy Landscapes Affect Phosphodiesterase Isoform-Specific Inhibitor Selectivity
Computational and Structural Biotechnology Journal, 2019 As human phosphodiesterase (PDE) proteins are attractive drug targets, a large number of selective PDE inhibitors have been developed. However, since the catalytic sites of PDE isoforms are conserved in sequence and structure, it remains unclear how ...
Qing Liu, Andreas Herrmann, Qiang Huang
doaj +1 more source
Antibody‐Empowered Nanomedicine for Precise Biomedical Applications
Advanced Science, EarlyView.This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen +7 more
wiley +1 more source
ZZE-Configuration of chromophore ß-153 in C-phycocyanin from Mastigocladus laminosus [PDF]
, 1987 The photochemistry of C-phycocyanin has been studied after denaturation in the dark. It shows an irreversible reaction which has characteristics of a Ζ,Ζ,Ε- to Z,Z,Z-isomerization of dihydrobilins. Its amplitude depends on the reaction conditions, with
Bode, W. +7 more
core +1 more source