Results 131 to 140 of about 2,886,292 (384)

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice. [PDF]

Biomedicines, 2022
Seo DH, Shin E, Lee YH, Park SE, Nam KT, Kim JW, Cha BS.   +6 more
europepmc   +1 more source

Trials of the bronchodilator activity of the isoenzyme-selective phosphodiesterase inhibitor AH 21-132 in healthy volunteers during a methacholine challenge test.

British Journal of Clinical Pharmacology, 1992
1. An approximately steady-state reduction of specific airway conductance was induced in normal human subjects by means of a methacholine individualized loading+maintenance dose regime.
R. Foster, K. Rakshi, J. R. Carpenter, RC Small   +3 more
semanticscholar   +1 more source

The current treatment of erectile dysfunction [PDF]

, 2016
Erectile dysfunction (ED) is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. It is the most frequent sexual dysfunction in elderly men and its prevalence increases with age.
Benea, Vasile, Georgescu, Simona R., Mitran, Cristina I., Mitran, Mădălina I., Sarbu, Maria Isabela, Tampa, Mircea   +5 more
core   +2 more sources

What Does Iron Mean to an Oligodendrocyte?

Glia, EarlyView.
ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions. The brain has the highest rate of energy consumption, and within the brain, oligodendrocytes have the highest level of oxidative metabolism per volume. Oligodendrocytes also stain the strongest for iron.
Quinn W. Wade, James R. Connor
wiley   +1 more source

The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor

Acta Pharmaceutica, 2015
PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated.
Suzuki Osamu, Goto Taiji, Yoshino Toshiharu, Nakamura Satoshi, Maeda Hiroaki   +4 more
doaj   +1 more source

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide

Frontiers in Neuroscience, 2019
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms, Frank S. Menniti, Christopher J. Schmidt   +2 more
doaj   +1 more source

Phosphodiesterase inhibitor for heart failure with preserved ejection fraction: A systematic review and meta-analysis. [PDF]

Saudi Pharm J, 2022
Chen Z, Zhao K, Xiao C, He Z, Liu S, Wu X, Shi S, Guo Y.   +7 more
europepmc   +1 more source

The Effects of Cyclic Nucleotide Phosphodiesterase Inhibitors on Ejaculated Porcine Spermatozoan Metabolism1 [PDF]

, 1973
David L. Garbers, Neal L. First, Sharon K. Gorman, Henry A. Lardy   +3 more
openalex   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source