Results 151 to 160 of about 2,886,292 (384)

The Adenylate Cyclase Activator Forskolin Potentiates the Positive Inotropic Effect of the Phosphodiesterase Inhibitor Milrinone But Not of the Calcium Sensitizer Levosimendan nor of Its Hemodynamically Active Metabolites: An Apparent Conundrum. [PDF]

J Cardiovasc Pharmacol, 2022
Levijoki J, Pollesello P, Pollesello P, Grossini E, Papp Z.   +4 more
europepmc   +1 more source

Perspectives on Ensifentrine and Its Therapeutic Potential in the Treatment of COPD: Evidence to Date

International Journal of COPD
Muhammad Asad Faruqi,1 Malik M Khurram S Khan,1 David M Mannino1,2 1University of Kentucky College of Medicine, Lexington, KY, USA; 2COPD Foundation, Miami, FL, USACorrespondence: David M Mannino, Department of Medicine, University of Kentucky College of
Faruqi MA, Khan MMKS, Mannino DM
doaj  

A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors [PDF]

, 1982
K Gietzen, I Sadorf, Hermann Bader
openalex   +1 more source

Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension

Drug, Healthcare and Patient Safety, 2015
Andrew L Dodgen,1 Kevin D Hill1,2 1Department of Pediatrics, Duke University Medical Center, 2Duke Clinical Research Institute, Durham, NC, USA Abstract: Sildenafil is a phosphodiesterase type-5 inhibitor approved for treatment of pulmonary arterial ...
Dodgen AL, Hill KD
doaj  

Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma

Frontiers in Cellular Neuroscience
IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran, Ning Hu, Catherine J. Kane, Steven H. Green   +3 more
doaj   +1 more source

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes [PDF]

, 1986
C M Heyworth, A M Grey, Sally Wilson, Emanuel Hanski, Miles D. Houslay   +4 more
openalex   +1 more source

EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder

Movement Disorders, EarlyView.
ABSTRACT Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document the first case of CMMs spontaneously occurring in Weimaraner dogs and to identify the underlying genetic ...
Cleo Schwarz, Florian Bartenschlager, Olivia Kershaw, Judith Braun, Julien Guevar, Vidhya Jagannathan, Jörg T. Epplen, Wencke Reineking, Wolfgang Baumgärtner, Kailash P. Bhatia, Achim D. Gruber, Tosso Leeb   +11 more
wiley   +1 more source

The effect of K-252a, a potent microbial inhibitor of protein kinase, on activated cyclic nucleotide phosphodiesterase [PDF]

, 1988
Y Matsuda, S. Nakanishi, Kunihiko Nagasawa, K Iwahashi, Hiroshi Kase   +4 more
openalex   +1 more source

Early‐Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B

Movement Disorders, EarlyView.
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg, Noam Hadar, Eyal Kristal, Nicola Y. Roberts, Vadim Dolgin, Ilana Aminov, Amit Safran, Nadav Agam, Matan Jean, Ofek Freund, Eamonn G. Sheridan, James A. Poulter, Michelle L. Thompson, Yusra Algoos, Salma Al‐Qahtani, Lama AlAbdi, Sateesh Maddirevula, Verity Hartill, Henry Houlden, Reza Maroofian, Amit Nahum, Ohad S. Birk   +21 more
wiley   +1 more source

Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension

Vascular Health and Risk Management, 2008
Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S MacdonaldHeart Lung Transplant Unit, St Vincent’s Hospital, Sydney, New South Wales, AustraliaAbstract: Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE-5).
Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S Macdonald   +3 more
doaj