Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values [PDF]
, 1988 Gerard J. Murphy, Miles D. Houslay
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Obesity, EarlyView.Abstract Objective Fat taste sensitivity has been implicated in long‐term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients. Methods Obesity‐induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform ...
Arnaud Bernard +5 more
wiley +1 more source
A heat‐stable inhibitor protein for bovine brain cyclic nucleotide phosphodiesterase from Escherichia coli [PDF]
, 1981 Yasushi Iwasa +4 more
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Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]
, 2008 Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama +4 more
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PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Background Capillary blood collection has a number of advantages over venous collection, especially in the context of increasing decentralized clinical trials and field‐based testing. No studies are available comparing venous versus capillary blood collection for proteomics measurement.
Mary Ni Lochlainn +4 more
wiley +1 more source
Stimulatory effects of adenosine, adenosine analogs and insulin on adipose tissue lipoprotein lipase activity and their prevention by phosphodiesterase inhibitors [PDF]
, 1984 Anne-Marie Bourdeaux +2 more
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Bioinformatics‐Based Comparative Analysis of the Human Retina Proteome
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Introduction The human retina relies on a complex network of proteins, many of which exhibit intrinsic disorder and liquid‐liquid phase separation (LLPS), enabling dynamic interactions for retinal function. Disruptions in these properties, along with missense mutations, have been linked to retinal diseases.
Colin K. Kim +8 more
wiley +1 more source
EFFECTS OF CYCLIC AMP‐ AND CYCLIC GMP‐PHOSPHODIESTERASE INHIBITORS ON IMMUNOLOGICAL RELEASE OF HISTAMINE AND ON LUNG CONTRACTION [PDF]
, 1981 Nelly Frossard +3 more
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United European Gastroenterology Journal, EarlyView.ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n
Lichieh Julie Chu +6 more
wiley +1 more source
Prolonged priapism following single dose administration of sildenafil: A rare case report
Urology Annals, 2009 A case of priapism following the consumption of a single dose of sildenafil is reported. A 25-year-old unmarried healthy man consumed non-prescribed 50 mg sildenafil purchased over the counter.
Sharma Sachit +5 more
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