Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity [PDF]
, 2010 Mariarosaria Bucci +8 more
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Medicine Bulletin, EarlyView.This study elucidates the nephrotoxic mechanism of acetyl tributyl citrate (ATBC) by integrating network toxicology, machine learning, and single‑cell multi‑omics analysis to systematically decipher the molecular mechanisms and cell‑type‑specific regulatory networks underlying ATBC‑induced kidney injury. First, a protein‑protein interaction network was
Yimao Wu +5 more
wiley +1 more source
217. Long-Term 52-Week Results of Palace 1, A Phase 3, Randomized, Controlled Trial of Apremilast, an Oral Phosphodiesterase Inhibitor, In atients with Psoriatic Arthritis [PDF]
, 2014 Adewale Adebajo +7 more
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Post Activation Potentiation Is Greater in Human Triceps Brachii Versus Triceps Surae Muscles
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Voluntary muscle contractions result in a temporary increase in twitch force, a phenomenon termed post activation potentiation (PAP). In rodents and other species, PAP is observed predominantly or exclusively in fast twitch muscles. However, it has been suggested that in humans, PAP occurs more or less independently of muscle
William S. Zoughaib +4 more
wiley +1 more source
Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents [PDF]
, 2023 Alexandra L. Zakharenko +9 more
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Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management
Rheumatology &Autoimmunity, EarlyView.Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley +1 more source
Respirology, EarlyView.Pulmonary arterial baroreceptors reflexively stimulate sympathetic nerve activity (SNA) in response to elevated pulmonary artery pressure and distension. In pulmonary hypertension patients, changes in muscle SNA were proportional to changes in pulmonary haemodynamics following nebulised iloprost.
Michael J. Plunkett +6 more
wiley +1 more source
UroPrecision, EarlyView.ABSTRACT Holmium laser enucleation of the prostate (HoLEP) has emerged as a widely adopted surgical technique for the management of benign prostatic hyperplasia (BPH), regardless of prostate size; however, its impact on male sexual function—particularly in terms of erectile and ejaculatory outcomes—remains a subject of ongoing debate.
Muhammed Arif İbiş +5 more
wiley +1 more source
A model protocol for the cryopreservation and recovery of motile lizard sperm using the phosphodiesterase inhibitor caffeine. [PDF]
Conserv Physiol, 2020 Campbell L +6 more
europepmc +1 more source
Penile traction therapy after radical pelvic surgery: Does it work?
UroPrecision, EarlyView.Abstract Sexual dysfunction, including erectile dysfunction and penile shortening, is a frequent consequence of radical pelvic surgeries such as prostatectomy, cystoprostatectomy, and rectal cancer surgery. These complications primarily result from nerve injury and hypoxia‐induced corporal fibrosis.
Ahmet Tevfik Albayrak +1 more
wiley +1 more source