Results 201 to 210 of about 2,886,292 (384)

Characterization of Forskolin-Induced Ca2+ Signals in Rat Olfactory Receptor Neurons

Journal of Pharmacological Sciences, 2005
Forskolin-induced Ca2+ signals were examined in isolated rat olfactory receptor neurons (ORNs) using a Ca2+ indicator, fura-2. In the soma of the ORNs, forskolin caused an increase in the intracellular Ca2+ concentration ([Ca2+]i) that was enhanced by a ...
Ken-ichi Otsuguro, Shree Hari Gautam, Shigeo Ito, Yoshiaki Habara, Toshiyuki Saito   +4 more
doaj  

Phosphodiesterase 4 inhibitor and phosphodiesterase 5 inhibitor combination therapy has antifibrotic and anti‐inflammatory effects in mdx mice with Duchenne muscular dystrophy

The FASEB Journal, 2017
Yasunori Nio, Masayuki Tanaka, Yoshihiko Hirozane, Yo Muraki, Mitsugi Okawara, M. Hazama, T. Matsuo   +6 more
semanticscholar   +1 more source

Risk of priapism after dynamic penile Doppler ultrasound: Single‐centre experience on a large cohort of patients

Andrology, EarlyView.
Abstract Objectives To evaluate the risk of priapism in patients undergoing Dynamic—Penile duplex ultrasound (D‐PDU) who were referred to our Unit between January 2022 and December 2023. Patients and methods We enrolled 292 patients, of whom 268 underwent Dynamic—Penile duplex ultrasound for erectile dysfunction and 24 for Peyronie's disease.
Giuseppe Grande, Andrea Graziani, Raffaele Scafa, Andrea Delbarba, Nicola Caretta, Pierfrancesco Palego, Alberto Ferlin   +6 more
wiley   +1 more source

Low‐intensity shockwave therapy for erectile dysfunction due to diabetes mellitus or coronary artery disease: An individual participant data meta‐analysis from a single center

Andrology, EarlyView.
Abstract Background Low‐intensity shockwave therapy (LiST) is a first‐line treatment for vasculogenic erectile dysfunction (ED). However, its efficacy in challenging cases, such as ED solely due to type 2 diabetes mellitus (DM) or coronary artery disease (CAD), has not been adequately assessed.
Nikolaos Pyrgidis, Dimitrios Kalyvianakis, Ioannis Mykoniatis, Dimitrios Hatzichristou   +3 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, EarlyView.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function [PDF]

, 1990
Kenneth Murray, P. England, Trevor J. Hallam, J.P. Maguire, Kitty Moores, Martin L. Reeves, Alec W.M. Simpson, T J Rink   +7 more
openalex   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, EarlyView.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.

, 1983
T Yamamoto, S Yamamoto, James C. Osborne, Vincent C. Manganiello, M Vaughan, Hisashi Hidaka   +5 more
openalex   +1 more source

Magnetic resonance imaging‐guided transurethral ultrasound ablation for benign prostatic obstruction: 1‐year clinical outcomes of a phase II study

BJU International, EarlyView.
Objectives To evaluate the safety and efficacy of magnetic resonance imaging (MRI)‐guided transurethral ultrasound ablation (TULSA) as a minimally invasive alternative for benign prostatic obstruction (BPO). Patients and Methods This prospective, single‐centre, early phase II study (NCT03350529) included 30 men with BPO scheduled for primary ...
Antti Viitala, Mikael Anttinen, Pietari Mäkelä, Heikki Pärssinen, Pertti Nurminen, Teija Sainio, Jani Saunavaara, Pekka Taimen, Roberto Blanco Sequeiros, Peter J. Boström   +9 more
wiley   +1 more source