Results 221 to 230 of about 2,886,292 (384)

The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction. [PDF]

Asian J Androl, 2019
Cho MC, Lee J, Park J, Oh S, Chai JS, Son H, Paick JS, Kim SW.   +7 more
europepmc   +1 more source

Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid.

, 1985
Shuji Takahashi, Fumio Nakagawa, Kayoko Kawazoe, Yoji Furukawa, Sadao Sato, Chihiro Tamura, Atsushi Naito   +6 more
openalex   +2 more sources

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor KS-619-1.

, 1987
Tohru Yasuzawa, Mayumi Yoshida, Kunikatsu Shirahata, Hiroshi Sano   +3 more
openalex   +2 more sources

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Inhibitors of cyclic adenosine 3',5'-monophosphate phosphodiesterase in Phyllostachys nigra MUNRO var. henonis STAPF. and Phragmites communis TRIN., and inhibition by related compounds.

, 1984
Tamotsu Nikaido, YEOLIK SUNG, Taichi Ohmoto, Ushio Sankawa   +3 more
openalex   +2 more sources

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer [PDF]

, 1996
John E. Souness, Miriam Griffin, Christopher Maslen, Karen Ebsworth, Lisa C. Scott, Kenneth H. Pollock, Malcolm N. Palfreyman, Jan‐Anders Karlsson   +7 more
openalex   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

Effect of cyclic AMP and phosphodiesterase inhibitors on muricide in olfactory bulbectomyzed rat

, 1987
Tatsuo Mizokawa, Kiyo Kimura, Yukihiro Ikoma, Kimio Hara, Tsuneyuki Yamamoto, Showa Ueki   +5 more
openalex   +1 more source

The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide [PDF]

, 1996
Saleh Al‐Alaiyan, Abbas Al-Omran, David Dyer   +2 more
openalex   +1 more source