Results 241 to 250 of about 2,886,292 (384)

Rolipram, a Selective Inhibitor of Phosphodiesterase Type 4, Pronouncedly Enhanced the Forskolin-Induced Promotion of Dopamine Biosynthesis in Primary Cultured Rat Mesencephalic Neurons.

, 1997
Nobuyuki Yamashita, Mio Miyashiro, Jun Baba, Aiko Sawa   +3 more
openalex   +2 more sources

Roflumilast in Dermatology: A Newer Phosphodiesterase-4 Inhibitor

Indian Journal of Dermatology
Suvesh Singh, Debopriya Paul, Aditi Snehal   +2 more
doaj   +1 more source

Inhibitory effect of a novel selective and potent phosphodiesterase type V inhibitor, E4021, on ST segment elevation induced by vasopressin in anesthetized guinea pigs.

, 1994
Kohtarou Kodama, Hideyuki Adachi, Nobuyuki Mori   +2 more
openalex   +1 more source

Modulation of spasmogen‐stimulated Ins(1,4,5)P₃ generation and functional responses by selective inhibitors of types 3 and 4 phosphodiesterase in airways smooth muscle [PDF]

, 1998
R. A. John Challiss, David Adams, Rajendra Mistry, C. D. Nicholson   +3 more
openalex   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Phosphodiesterase 4 inhibitors and db‐cAMP inhibit TNF‐α release from human mononuclear cells. Effects of cAMP and cGMP‐dependent protein kinase inhibitors [PDF]

, 1996
Aziz Hichami, Elisabeth Boichot, Nicolas Germain, E.V. Berdyshev, Olivier Coqueret, Vincent Lagente   +5 more
openalex   +1 more source

Evaluating the outcomes of pluripotent stem‐cell‐derived photoreceptor transplantation in retinal repair

The FEBS Journal, EarlyView.
Transplantation of stem cell‐derived photoreceptors in retinal repair. We summarize methods for differentiating stem cells and describe surgical techniques for transplanting photoreceptor precursors to restore visual function (A). The effectiveness of these techniques is assessed with behavioral (B) and in vitro assays (C) using mouse models that mimic
Darin Zerti, Birthe Dorgau, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako, Gerrit Hilgen   +5 more
wiley   +1 more source

Metabolic products of microorganisms. 268. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. II. Minor components belonging to the obscurolide B to D series.

, 1993
M. RITZAU, SIEGRID PHILIPPS, Axel Zeeck, HUBERT HOFF, Hans Zähner   +4 more
openalex   +2 more sources

Characterization of phosphodiesterase 4 in guinea‐pig macrophages: multiple activities, association states and sensitivity to selective inhibitors [PDF]

, 1998
John J. Kelly, Peter J. Barnes, Mark A. Giembycz   +2 more
openalex   +1 more source

The effects of caffeine and adenosine on the microbiome and lipidome of the scalp

International Journal of Cosmetic Science, EarlyView.
At 12 weeks, anti‐hair loss effects were evident with decreased Pseudomonas, Escherichia‐Shigella and Malassezia and increased Talaromyces and Cutibacterium. Lipid levels were impacted, correlating with Escherichia‐Shigella and Talaromyces. Abstract Hair loss is a complex multifactorial process.
Fengzhu Li, Shulin Liu, Zhaoying Han, Yingtian Li, Haowei Chen, Qingying Shi, Jie Tan, Xihong He, Xinyan Liu, Huabing Zhao, Fang Wang   +10 more
wiley   +1 more source