Results 291 to 300 of about 2,974,682 (398)

Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism. [PDF]

J Neurochem
d'Anglemont de Tassigny X, Jiménez-Medina A, López-López I, López-Barneo J.   +3 more
europepmc   +1 more source

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia

, 2019
Yinuo Wu, Qian Zhou, Tianhua Zhang, Zhe Li, Yiping Chen, Pei Zhang, Yan-Fa Yu, Haiju Geng, Yi‐Jing Tian, Chen Zhang, Yu Wang, Jianwen Chen, Yan Chen, Hai‐Bin Luo, Yan Chen, Hai-Bin Luo   +15 more
openalex   +1 more source

Safety and efficacy of Rezūm water vapour energy therapy in BPH patients receiving antithrombotic therapy: A Japanese single‐centre experience

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives The objective of this study is to evaluate the safety and efficacy of Rezūm water vapour energy therapy (WAVE) in Japanese patients with benign prostatic hyperplasia (BPH) continuing antithrombotic therapy and to validate the Okayama University Modified Clavien‐Dindo classification (OU‐mCD) for perioperative hematuria.
Takatoshi Moriwake, Yusuke Tominaga, Satoshi Katayama, Haruki Kaku, Ichiro Tsuboi, Kasumi Yoshinaga, Tomoaki Yamanoi, Tatsushi Kawada, Takuya Sadahira, Takehiro Iwata, Shingo Nishimura, Kensuke Bekku, Yasuhiro Katayama, Motoo Araki   +13 more
wiley   +1 more source

Editorial: Bridging Inflammation, Oxidative Stress, and Metabolic Dysfunction in Brain Disorders. [PDF]

Brain Sci
Akhtar A.
europepmc   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Sildenafil helps the beat go on

Experimental Physiology, EarlyView.
Jules C. Hancox
wiley   +1 more source

Static Stretching Acutely Reduces the Ergogenic Effects of Caffeine on Sprint Performance but Not Maximal Ball Velocity in Football Players

European Journal of Sport Science, Volume 26, Issue 2, February 2026.
ABSTRACT This study aimed to investigate the independent and combined effects of caffeine and static stretching (SS) on maximal ball velocity and 30‐m sprint performance. Sixteen male amateur football players performed 30‐m sprint and an instep kicking ball velocity test under six conditions.
Refik Çabuk, İzzet İslamoğlu, Onur Demirarar, Faruk Albay, Yıldırım Kayacan   +4 more
wiley   +1 more source

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Farouk Boudou, Alaeddine Berkane, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, Brian A. Murray, Mikhael Bechelany, Ahmed Barhoum   +7 more
wiley   +1 more source

Real-World Adherence and Persistence of Upfront Therapy in Patients with Pulmonary Arterial Hypertension in the United States. [PDF]

Pulm Ther
De Marco T, Paoli CJ, Croteau NS, Tang F, Farber HW.   +4 more
europepmc   +1 more source