Results 301 to 310 of about 2,888,163 (384)

A cAMP-Specific Phosphodiesterase Inhibitor Preserves the Motility of Washed Human Sperm

, 1997
J Fisch
openalex   +1 more source

MdDSK2a‐Like‐MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition

Advanced Science, Volume 12, Issue 26, July 10, 2025.
Under cold stress, MdDSK2a‐like is degraded via the 26S proteasome pathway, thereby alleviating the degradation of MdMTA induced by the 26S proteasome and autophagy pathways mediated by MdDSK2a‐like. The accumulated MdMTA increases the m6A levels of cold‐responsive genes, thereby contributing to increased ROS detoxification, deposition of cell wall, as
Nan Hou, Jieqiang He, Chana Bao, Fang Zhi, Xiaoxia Shen, Yu Liu, Chaoshuo Li, Tianle Fan, Xinyue Yang, Baohua Chu, Gege Qin, Zeyuan Liu, Chuang Mei, Bin Tan, Jiancan Feng, Fengwang Ma, Mickael Malnoy, Xuewei Li, Qingmei Guan   +18 more
wiley   +1 more source

Anti-Inflammatory Activity of Ensifentrine: A Novel, Selective Dual Inhibitor of Phosphodiesterase 3 and Phosphodiesterase 4.

Respiration
Spina D, Franciosi L, Venkatasamy R, Saint DA, MacDonald-Berko M, Rheault T.   +5 more
europepmc   +1 more source

Advancing Obstructive Airway Disease Treatment: Dual PDE3/4 Inhibition as a Therapeutic Strategy. [PDF]

Cells
Sherpa RT, Koziol-White CJ, Panettieri RA.   +2 more
europepmc   +1 more source

Postoperative bilateral visual loss after a single dose of tranexamic acid

Anaesthesia Reports, Volume 13, Issue 2, July‐December 2025.
Summary A 32‐year‐old woman presented with transient visual loss following the intra‐operative administration of a single intravenous dose of tranexamic acid during urgent cholecystectomy. Apart from obesity, the patient had no notable medical history or pre‐existing ocular conditions.
B. Chevalley, M. Betello, E. Blavakis, A. Malclès, J. Maillard   +4 more
wiley   +1 more source

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 929-941, July 2025.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 242-251, July 2025.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Ensifentrine: A Novel Option for Maintenance of Chronic Obstructive Pulmonary Disease. [PDF]

J Pharm Technol
Hitt EM, Powell AJ.
europepmc   +1 more source

FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
FTO regulates the translation of IGFBP3 by demethylating m6A sites in the 3′‐untranslated region of IGFBP3 mRNA. Binding of the m6A reader protein IMP3 to 3′UTR m6A sites in IGFBP3 mRNA promoted its localisation and sequestration in cellular organelles known as to P‐bodies, thereby suppressing IGFBP3 mRNA translation. IGFBP3 regulates activation of the
Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li   +7 more
wiley   +1 more source

Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation. [PDF]

Int J Neuropsychopharmacol
Guo TY, Zhang M, Lv YL, Qiu NZ, Chen RM, Zhang FF, Chen W, Zhang F, Gao YF, Wang XD, Zhang XH, Chen MH, Zhang HT, Wang H.   +13 more
europepmc   +1 more source