Results 311 to 320 of about 2,888,163 (384)

Demonstration of a Heat-Stable Cyclic GMP Phosphodiesterase in the Medium of Physarum flavicomum [PDF]

, 1985
Lynch, Thomas J., Ross, Mark S.
core   +2 more sources

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

Glia, Volume 73, Issue 7, Page 1383-1397, July 2025.
Main Points Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying ...
Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
wiley   +1 more source

Myricetin Amplifies Glucose-Stimulated Insulin Secretion via the cAMP-PKA-Epac-2 Signaling Cascade. [PDF]

Biomedicines
Ali A, Memon Z, Hameed A, Ul-Haq Z, Ali M, Hafizur RM.   +5 more
europepmc   +1 more source

Hailey‐Hailey Disease: An Updated Review With a Focus on Therapeutic Mechanisms

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background Hailey‐Hailey disease (HHD), or familial benign chronic pemphigus, is a rare autosomal dominant genodermatosis characterized by chronic, painful, erythematous, erosive plaques and fissures at sites of friction such as the neck, axilla, groin, and perineum.
Mahesh Mathur, Sumit Paudel, Nabita Bhattarai, Sambidha Karki, Sandhya Regmi   +4 more
wiley   +1 more source

Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3xTg-AD mice via PDE4B/cAMP/PKA signaling. [PDF]

Int J Neuropsychopharmacol
Sun R, Han M, Lin Y, Ma S, Tu H, Yang X, Zhang F, Zhang HT.   +7 more
europepmc   +1 more source

Notum as a Crucial Regulator of Matrix Integrity in Dentinogenesis

Journal of Cellular Physiology, Volume 240, Issue 7, July 2025.
With Notum deficiency, mouse dentin exhibits a thicker yet dysplastic structure with disrupted tubular organization, resulting in functionally compromised dentin. Notum precisely regulates Wnt/β‐catenin signaling within the dentin‐pulp complex to support dentin formation.
Hwajung Choi, Ju‐Kyung Jeong, Dinuka Adasooriya, Sung‐Won Cho, Eui‐Sic Cho   +4 more
wiley   +1 more source

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease. [PDF]

BJU Int
Harding SL, Ilg MM, Bustin SA, Ralph DJ, Cellek S.   +4 more
europepmc   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation. [PDF]

J Am Heart Assoc
Cedars A, Manlhiot C, Chinni BK, Opotowsky AR, Becker K, Le A, Khare P, Love Ko J, Everett A, Kutty S, Russell MW, Payne RM, Atz AM, McCrindle BW, Rathod RH, Lewis M, Goldberg D, Hill K, Ploutz M, Detterich J, Schumacher K, Whitehill R, Penny DJ, Cartoski M, Sullivan R, Files M, Garg R, Wagner J, Jacobsen R, Nowlen T, Fletcher S, Conway J, Kim GB, Wu F, Zak V.   +34 more
europepmc   +1 more source

Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded

MedComm, Volume 6, Issue 7, July 2025.
Phosphate serves as a building block for physiological mineralization, and as a signaling molecule that regulates the activity of mineralizing cells. The disturbance in these processes could induce a series of pathological mineralization, with abnormal mineralization of hard tissues and ectopic mineralization of soft tissues being the most ...
Wen Qin, San‐yang Yu, Jia‐lu Gao, Jian‐fei Yan, Qian‐qian Wan, Shuai‐lin Jia, Franklin Tay, Kai Jiao, Lina Niu   +8 more
wiley   +1 more source