Drug, Healthcare and Patient Safety, 2015 Andrew L Dodgen,1 Kevin D Hill1,2 1Department of Pediatrics, Duke University Medical Center, 2Duke Clinical Research Institute, Durham, NC, USA Abstract: Sildenafil is a phosphodiesterase type-5 inhibitor approved for treatment of pulmonary arterial ...
Dodgen AL, Hill KD
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Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma
Frontiers in Cellular NeuroscienceIntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran +3 more
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The Adenylate Cyclase Activator Forskolin Potentiates the Positive Inotropic Effect of the Phosphodiesterase Inhibitor Milrinone But Not of the Calcium Sensitizer Levosimendan nor of Its Hemodynamically Active Metabolites: An Apparent Conundrum. [PDF]
J Cardiovasc Pharmacol, 2022 Levijoki J +4 more
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Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients. [PDF]
Front Immunol, 2022 Leukes VN +9 more
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Evolution of Phosphodiesterase-5 Inhibitors
The World Journal of Men's Health, 2015 After the launch of sildenafil citrate (Viagra®), the last great invention of the 20th century, in 1998, oral phosphodiesterase (PDE)-5 inhibitors were established as first-line treatment for erectile dysfunction (ED), representing a paradigm shift in the diagnosis and treatment of ED [1].
openaire +2 more sources
International Journal of COPDMuhammad Asad Faruqi,1 Malik M Khurram S Khan,1 David M Mannino1,2 1University of Kentucky College of Medicine, Lexington, KY, USA; 2COPD Foundation, Miami, FL, USACorrespondence: David M Mannino, Department of Medicine, University of Kentucky College of
Faruqi MA, Khan MMKS, Mannino DM
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Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension
Vascular Health and Risk Management, 2008 Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S MacdonaldHeart Lung Transplant Unit, St Vincent’s Hospital, Sydney, New South Wales, AustraliaAbstract: Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE-5).
Anne M Keogh +3 more
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Potential Roles of PDE4 Inhibitors in Peptic Ulcer Treatment
Клинический разбор в общей медицинеIntroduction. Peptic ulcer disease, a common gastrointestinal disorder, is mostly caused by Helicobacter pylori infection, non-steroidal anti-inflammatory drug usage, and lifestyle factors including alcohol use and smoking.
Khaled A. Abdel-Sater
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Prolonged priapism following single dose administration of sildenafil: A rare case report
Urology Annals, 2009 A case of priapism following the consumption of a single dose of sildenafil is reported. A 25-year-old unmarried healthy man consumed non-prescribed 50 mg sildenafil purchased over the counter.
Sharma Sachit +5 more
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The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder
PharmaceuticalsAutism spectrum disorder (ASD) and Fragile X syndrome (FXS) are neurodevelopmental disorders marked by deficits in communication and social interaction, often accompanied by anxiety, seizures, and intellectual disability.
Shilu Deepa Thomas +5 more
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