Results 41 to 50 of about 54,797 (163)

Effect of phosphodiesterase inhibitors in the bladder

Asian Journal of Urology, 2015
Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H2S pathway.
Bilal Chughtai, Aizaz Ali, Claire Dunphy, Steven A. Kaplan   +3 more
openaire   +3 more sources

The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor

Acta Pharmaceutica, 2015
PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated.
Suzuki Osamu, Goto Taiji, Yoshino Toshiharu, Nakamura Satoshi, Maeda Hiroaki   +4 more
doaj   +1 more source

Nitric Oxide Signaling in Heart Failure With Preserved Ejection Fraction

JACC: Basic to Translational Science, 2017
Summary: There has been considerable focus on the potential role of nitric oxide (NO) and phosphodiesterase (PDE)-5 inhibition in treating heart failure with preserved ejection fraction (HFpEF). However, the results from studies have been conflicting. In
Lucas Cruz, MD, John J. Ryan, MD
doaj   +1 more source

Non-invasive alternative for phosphodiesterase inhibitor-refractory erectile dysfunction: Real-life experience with low-intensity extracorporeal shockwave therapy. [PDF]

Medicine (Baltimore), 2023
Bayraktar N.
europepmc   +1 more source

ZSP1601, a novel pan-phosphodiesterase inhibitor for the treatment of NAFLD, A randomized, placebo-controlled phase Ib/IIa trial. [PDF]

Nat Commun, 2023
Hu Y, Li H, Zhang H, Chen X, Chen J, Xu Z, You H, Dong R, Peng Y, Li J, Li X, Wu D, Zhang L, Cao D, Jin H, Qiu D, Yang A, Lou J, Zhu X, Niu J, Ding Y.   +20 more
europepmc   +1 more source

Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice. [PDF]

Biomedicines, 2022
Seo DH, Shin E, Lee YH, Park SE, Nam KT, Kim JW, Cha BS.   +6 more
europepmc   +1 more source

Phosphodiesterase inhibitor for heart failure with preserved ejection fraction: A systematic review and meta-analysis. [PDF]

Saudi Pharm J, 2022
Chen Z, Zhao K, Xiao C, He Z, Liu S, Wu X, Shi S, Guo Y.   +7 more
europepmc   +1 more source

Avanafil for treatment of erectile dysfunction: review of its potential

Vascular Health and Risk Management, 2012
Ryan M Burke,1 Jeffery D Evans21The University of Louisiana at Monroe College of Pharmacy, Monroe, LA, 2The University of Louisiana at Monroe College of Pharmacy, Shreveport, LA, USAAbstract: Avanafil is a medication that was recently approved by the US ...
Burke RM, Evans JD
doaj  

The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Mice. [PDF]

Front Cell Infect Microbiol, 2022
Barbieri D, Gomez L, Royer L, Dupuy F, Franetich JF, Tefit M, N'Dri ME, Mazier D, Silvie O, Moreno-Sabater A, Lavazec C.   +10 more
europepmc   +1 more source

Analyzing the Clinical Efficacy of a Type 5 Phosphodiesterase Inhibitor Combined With Ziyin Baihuo Granules in the Treatment of Erectile Dysfunction. [PDF]

Am J Mens Health, 2022
Wang R, Sun WG, Zhang TB, Zheng T, Lv KL, Nan YH, Zhang WX.   +6 more
europepmc   +1 more source