Results 21 to 30 of about 54,797 (163)
Research progress of phosphodiesterase 5 in heart failure [PDF]
Jichu yixue yu linchuangPhosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and
YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei
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ASN Neuro, 2021 The mammalian circadian clock at the hypothalamic suprachiasmatic nuclei (SCN) entrains biological rhythms to the 24-h cyclic environment, by encoding light-dark transitions in SCN neurons.
Santiago Andrés Plano +5 more
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PLoS ONE, 2019 IntroductionCurrent treatments for overactive bladder (OAB) are often discontinued due to side effects or lack of efficacy. The goal of this study was to determine if combining a phosphodiesterase type 4 inhibitor (PDE4i); with a type 5 inhibitor (PDE5i);
Brian M Balog +7 more
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Sildenafil in Infants and Children
Children, 2017 Pulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy.
Larisa Simonca, Robert Tulloh
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Frontiers in Medicine, 2023 Study designSystematic review.ObjectiveThe objective of this study was to evaluate the impact of phosphodiesterase (PDE) inhibitors on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury (SCI).MethodsA ...
Max B. Butler +20 more
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New in treatment of hyperactive bladder with urge urinary incontinence in women
Бюллетень сибирской медицины, 2012 The combination of α1 adrenoceptor blocking agent and phosphodiesterase inhibitor of 5th type is efficient in treatment of women with hyperactive bladder and urge urinary incontinence, which was proved by the studies of urodynamic and microcirculation ...
A. I. Neimark +2 more
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Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. [PDF]
PLoS ONE, 2013 Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Trinity J Bivalacqua +5 more
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Научно-практическая ревматология, 2017 Resolution of the Council of Experts on «The place of phosphodiesterase-4 inhibitor in the combination treatment of moderate to severe psoriasis and active psoriatic arthritis».
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Role of phosphodiesterase in glucagon resistance of large adipocytes
Journal of Lipid Research, 1974 The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter ≃ 45 μm) and large (mean diameter ≃ 78 μm ...
Richard A. De Santis +3 more
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Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors
Brazilian Journal of Pharmaceutical Sciences, 2020 Phosphodiesterases (PDE) are group of enzymes which catalyze the hydrolysis of cAMP and cGMP. Since these cyclic phosphate moieties worked as intracellular second messengers in numerous physiological processes, their inhibition can affect normal ...
Shumaila Tasneem +2 more
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