Results 11 to 20 of about 54,797 (163)

Phosphodiesterase inhibitors [PDF]

British Journal of Pharmacology, 2006
Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and thus play a key role in regulating intracellular levels of the second messengers cAMP and cGMP, and hence cell function. Theophylline and papaverine have historically been used therapeutically and are known to be weak inhibitors of PDE, but to what extent this ...
Boswell-Smith, V, Spina, D, Page, C P
openaire   +3 more sources

Phosphodiesterase Inhibitors [PDF]

International Cardiovascular Forum Journal, 2019
Phosphodiesterases (PDEs) comprise a superfamily with 11 subfamilies. Within these families, more than 40 isoforms are expressed. Phosphodiesterase-3 inhibitors (PDE3i) are used as inotrope/vasodilators for acute heart failure (HF), and PDE5i for pulmonary hypertension and erectile dysfunction.
Rui Plácido, Mitja Lainscak
openaire   +2 more sources

Roflumilast: Review of Phosphodiesterase-4 Inhibitor as Asthma Therapy

Jurnal Ilmiah Kesehatan, 2021
Asthma is a heterogeneous disease characterized by chronic inflammation of the airways induced reversible obstruction resulting in mortality and morbidity. Roflumilast is a second-generation selective inhibitor of phosphodiesterase-4  targeting PDE type
Rafina Syfridiana, Fauna Herawati
doaj   +1 more source

Research of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelets aggregation activity in patients with heart failure and metabolic disturbances

Бюллетень сибирской медицины, 2012
Data of the study of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of the platelet aggregation activity in 25 patients with DM2 and heart failure are presented.
O. N. Ogurkova, T. Ye. Suslova, A. V. Sitoshevsky, O. A. Koshelskaya   +3 more
doaj   +1 more source

Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus

Nature Communications, 2023
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament ...
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermair, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke   +19 more
doaj   +1 more source

Roflumilast: A Review of Chronic Obstructive Pulmonary Disease (COPD) Treatment

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2021
Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway inflammation with resulting progressive airflow limitation that has a high incidence, morbidity, and mortality. Roflumilast is an oral phosphodiesterase-4 inhibitor as a therapy to decrease
Ita Octafia, Dwi Octamy Sari, Novi Wulandari, Sandra Annisa, Linda Wahyuni Wongkar, Ferdias Kurnia Bahari, Faiz Farikhah, Moh Firmansah, Erfin Midhiawati, Fauna Herawati   +9 more
doaj   +1 more source

Effectiveness of Phosphodiesterase-5 Inhibitor Therapy for Portopulmonary Hypertension

Canadian Respiratory Journal, 2015
BACKGROUND: Portopulmonary hypertension is associated with significant morbidity and mortality. Phosphodiesterase-5 inhibitor therapy is efficacious in other causes of WHO group I pulmonary arterial hypertension.
Jolene H Fisher, Sindhu R Johnson, Cathy Chau, Amie T Kron, John T Granton   +4 more
doaj   +1 more source

Synthesis, Tyrosinase Inhibiting Activity and Molecular Docking of Fluorinated Pyrazole Aldehydes as Phosphodiesterase Inhibitors

Applied Sciences, 2019
A series of fluorinated 4,5-dihydro-1H-pyrazole derivatives were synthesized in the reaction of corresponding acetophenone and different aldehydes followed by the second step synthesis of desired compounds from synthesized chalcone, hydrazine hydrate ...
Vesna Rastija, Harshad Brahmbhatt, Maja Molnar, Melita Lončarić, Ivica Strelec, Mario Komar, Valentina Pavić   +6 more
doaj   +1 more source

Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases

Frontiers in Microbiology, 2010
The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi.
Charu eAgarwal, David J Schultz, Michael H Perlin   +2 more
doaj   +1 more source

Effect of phosphodiesterase inhibitors on medication-related osteonecrosis of the jaw in mice: a comparison of phosphodiesterase-4 and phosphodiesterase-5 inhibition

Acta Odontologica Scandinavica
Objective: Medication-related osteonecrosis of the jaw lacks proven pharmacological prevention. We compared a phosphodiesterase-4 inhibitor rolipram and a phosphodiesterase-5 inhibitor sildenafil in a zoledronic acid– and dexamethasone–based mouse model ...
Yunus Baş, Olgun Topal, Gökhan Sadi, Esra Aslan, Halit Buğra Koca, Mehmet Bilgehan Pektaş   +5 more
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