Results 1 to 10 of about 54,747 (118)

Antifibrotic Strategies Targeting Phosphodiesterase-4 in Idiopathic Pulmonary Fibrosis: Molecular Mechanisms and Clinical Translation [PDF]

Clinical Pharmacology: Advances and Applications
Quan Ma,1,2 Shixin Zhou,3 Xiaodong Zhi,3 Caifeng Luo,4 Zhongbo Zhu,1 Xuhui Zhang,5 Xiping Liu1 1School of Basic Medical Sciences, Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, People’s Republic of China; 2Department of Lung Diseases,
Ma Q, Zhou S, Zhi X, Luo C, Zhu Z, Zhang X, Liu X   +6 more
doaj   +2 more sources

Effect of a three-piece inflatable penile prosthesis combined with a phosphodiesterase-5 inhibitor on erectile dysfunction

Journal of International Medical Research, 2021
Objective To investigate the therapeutic effect of implanting a three-piece inflatable penile prosthesis (IPP) combined with the phosphodiesterase-5 inhibitor sildenafil in severe erectile dysfunction (ED) patients.
Jian Wang, Peng Wu, Qiang Liu, Liangliang Ben, Geng Chen, Zhijuan Han, Hui Peng   +6 more
doaj   +1 more source

Apremilast

Turkderm Turkish Archives of Dermatology and Venereology, 2022
Apremilast is an orally used small-molecule inhibitor of phosphodiesterase-4. It has been approved for the treatment of adult patients with psoriatic arthritis and moderate to severe plaque psoriasis.
Nihal Kundakçı
doaj   +1 more source

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA. [PDF]

PLoS ONE, 2010
The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation.
Mitsunori Ishiguro, Keisuke Mishiro, Yasuyuki Fujiwara, Huayue Chen, Hiroshi Izuta, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Masahiko Satoh, Toru Iwama, Hideaki Hara   +10 more
doaj   +1 more source

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries

Reproductive Biology and Endocrinology, 2009
Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg, O'Toole Daniel, Maharaj Chrisen H, Carney John, Jarman James, Higgins Brendan D, Morrison John J, Laffey John G   +7 more
doaj   +1 more source

Hemorrhagic Cholecystitis in an Elderly Patient Taking Aspirin and Cilostazol

Case Reports in Gastroenterology, 2008
Hemorrhage is a rare complication of acute cholecystitis. Patients who develop this complication often are receiving anticoagulation therapy or have a pathologic coagulopathy.
David S. Morris, John R. Porterfield, Mark D. Sawyer   +2 more
doaj   +1 more source

Effect of vardenafil on diabetic foot ulcer (DFU) in rats

Zagazig Journal of Pharmaceutical Sciences, 2018
The present study was designed to investigate the possible effect of vardenafil phosphodiesterase-5 inhibitor on diabetic foot ulcer induced in rats and the underlying mechanism(s).
Hany Anwer , Waleed Barakat , Mona F Mahmoud   +2 more
doaj   +1 more source

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. [PDF]

PLoS ONE, 2011
BACKGROUND: Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many cell types. This cyclic nucleotide plays a key role in signal transduction in a wide variety of cellular responses.
Jose A Morales-Garcia, Miriam Redondo, Sandra Alonso-Gil, Carmen Gil, Concepción Perez, Ana Martinez, Angel Santos, Ana Perez-Castillo   +7 more
doaj   +1 more source

Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma

Allergology International, 2009
Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling. Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 and 1 dual inhibitor, on chronic airway inflammation and
Toshiyuki Kita, Masaki Fujimura, Shigeharu Myou, Kazuyoshi Watanabe, Yuko Waseda, Shinji Nakao   +5 more
doaj   +1 more source

Pharmacological analysis of the feeding response of codling moth (Cydia pomonella; Lepidoptera: Tortricidae) neonates to bitter compounds

European Journal of Entomology, 2017
Feeding in codling moth neonate caterpillars was inhibited by 0.67 mM and 2.24 mM concentrations of denatonium benzoate. This inhibitory effect was abolished by phospholipase C inhibitor, U-73122 and the phosphodiesterase inhibitor, Rolipram. Quinine and
Maciej A. PSZCZOLKOWSKI
doaj   +1 more source