Results 231 to 240 of about 27,465 (289)

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Polyethylene terephthalate (PET) primary degradation products affect c-di-GMP-, cAMP-signaling, and quorum sensing (QS) in <i>Vibrio gazogenes</i> DSM 21264. [PDF]

Microbiol Spectr
Preuss L, Alawi M, Dumnitch A, Trinh L, Maison W, Burmeister N, Poehlein A, Daniel R, Vollstedt C, Streit WR.   +9 more
europepmc   +1 more source

Functional outcomes and toxicity following focal low‐dose‐rate brachytherapy for low–intermediate risk prostate cancer

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives We aim to prospectively evaluate functional outcomes and toxicity following focal low‐dose‐rate (LDR) brachytherapy for low–intermediate risk prostate cancer (PCa). Patients and Methods LIBERATE is a clinical registry of men treated with focal LDR brachytherapy for low–intermediate risk PCa since September 2019.
Mohammadmehdi Adhami, Jeremy Cheng, Elliot Anderson, Lloyd Smyth, Cate Davey, Thang Nguyen, Richard O'Sullivan, Andrew Ryan, Nathan Lawrentschuk, Jeremy Grummet, Andrew See   +10 more
wiley   +1 more source

Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase. [PDF]

PLoS Genet
Trebino MA, Kitts G, Haycocks JRJ, Wheat R, Chaudry I, Park JH, Erill I, Grainger DC, Yildiz FH.   +8 more
europepmc   +1 more source

Cyclic nucleotide inactivation in osteoblasts and osteosarcoma cell lines [PDF]

, 2001
Ahlström, Mikael EB
core  

Outcomes of Aquablation in BPH with bladder stones: Analysis of the ICARUS database

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objective The purpose of this study is investigate the clinical outcomes of men with benign prostatic hyperplasia (BPH) and bladder stones treated concomitantly with Aquablation and bladder stone removal in an international, multi‐institutional cohort.
Joshua D. Cabral, Margaret Gannon, Gregory Raster, David J. Nusbaum, David Bouhadana, Adel Arezki, Aalya Hamouda, Anouk Leathead, Ilan Ohana, Rosie Foucault, Iman Sadri, Jeffrey A. Sioufi, Nick Lee, Tarek Benzouak, Liam Murad, Nicholas J. Corsi, John Klein, Inderjit Singh, James Kearns, Cecilia Chang, Juan Justo Quintas, Kevin C. Zorn, Tiago Rodrigues, Shawn H. Marhamati, Brian T. Helfand, Alexander P. Glaser   +25 more
wiley   +1 more source

Development of a Novel ¹⁸F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography. [PDF]

Mol Pharm
Rong J, Zhao C, Chaudhary AF, Jones E, Van R, Song Z, Li Y, Chen J, Zhou X, Patel JS, Gao Y, Sun Z, Feng S, Zhang Z, Collier TL, Ran C, Haider A, Shao Y, Yuan H, Liang SH.   +19 more
europepmc   +1 more source

Safety and efficacy of Rezūm water vapour energy therapy in BPH patients receiving antithrombotic therapy: A Japanese single‐centre experience

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives The objective of this study is to evaluate the safety and efficacy of Rezūm water vapour energy therapy (WAVE) in Japanese patients with benign prostatic hyperplasia (BPH) continuing antithrombotic therapy and to validate the Okayama University Modified Clavien‐Dindo classification (OU‐mCD) for perioperative hematuria.
Takatoshi Moriwake, Yusuke Tominaga, Satoshi Katayama, Haruki Kaku, Ichiro Tsuboi, Kasumi Yoshinaga, Tomoaki Yamanoi, Tatsushi Kawada, Takuya Sadahira, Takehiro Iwata, Shingo Nishimura, Kensuke Bekku, Yasuhiro Katayama, Motoo Araki   +13 more
wiley   +1 more source

Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study. [PDF]

Eur Heart J Cardiovasc Pharmacother
Xiao J, Zhang N, Gao Z, Wei Y, Wei H, Qiu Z, Sundquist K, Sundquist J, Ji J, Huang W.   +9 more
europepmc   +1 more source

GPCR signaling via cAMP nanodomains. [PDF]

Biochem J
Yadav R, Zaccolo M.
europepmc   +1 more source