Results 231 to 240 of about 17,744 (296)

Unveiling of phosphodiesterase-5 hot residues binding to xanthine derivatives for erectile dysfunction therapy: A computational drug repurposing approach. [PDF]

PLoS One
Elzupir AO, Almahmoud SAJ.
europepmc   +1 more source

Disarming the Pathogen's Metabolic Weapon: A Novel Route to Durable Disease Resistance

Modern Agriculture, Volume 4, Issue 1, June 2026.
Two routes to sugar acquisition in pathogenic bacteria and corresponding ‘pathogen‐starvation’ strategies. TAL effectors activate plant SWEET transporters to promote sucrose efflux into the apoplast, which can be blocked by editing SWEET promoter effector‐binding elements to prevent TAL binding. The T3E AvrBs2 converts host UDP‐galactose into xanthosan,
Yixuan Mi, Yuheng Yang
wiley   +1 more source

<i>Megalomyrmex milenae</i> Transcriptome Reveals a Complex Venom Cocktail. [PDF]

Toxins (Basel)
Sozanski KS, Coelho GR, Ishihara MA, Delgado A, Adams RMM.   +4 more
europepmc   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Emerging roles of pterins as signaling molecules in bacteria. [PDF]

Biochem Soc Trans
Rucker P, Augusta L, Fuqua C, Allen KD.
europepmc   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models. [PDF]

J Clin Invest
Kim J, Yoon H, Joe SC, Smith A, Park J, Hong G, Ha JM, Kim EB, Seki E, Kim MK, Lee HO, Kim HS, Chung JH.   +12 more
europepmc   +1 more source

cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights. [PDF]

Front Endocrinol (Lausanne)
Lima Sobrinho JAB, Almeida MQ.
europepmc   +1 more source

Finding the brakes on the Toxoplasma life cycle. [PDF]

Trends Parasitol
Herneisen AL, Lourido S.
europepmc   +1 more source