Water-saving guard cell-mesophyll cell model captures temporally differential enzymatic and transporter activities during C3-crassulacean acid metabolism transition. [PDF]
Plant PhysiolSarkar D, Kundu S.
europepmc +1 more source
Cytosolic PEPCK deficiency caused by a novel homozygous frame-shift variant presenting as resolved hypoglycemia and acute liver failure at birth. [PDF]
Mol Genet Metab RepBurg D +4 more
europepmc +1 more source
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Mitochondrial phosphoenolpyruvate carboxykinase deficiency
European Journal of Pediatrics, 1986A 3-month-old girl presented with anorexia, failure to thrive and drowsiness. She was mildly icteric with hepatomegaly and peripheral oedema. Disordered liver function tests were associated with the biopsy appearances of a giant cell hepatitis and with a Fanconi syndrome. At the age of 16 weeks she collapsed with profound hypoglycaemia.
M. P. Brand +3 more
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Inhibition of phosphoenolpyruvate carboxykinase by streptonigrin
Biochemical Pharmacology, 1982Streptonigrin, an antibiotic with antineoplastic activity, inhibited rat liver phosphoenolpyruvate carboxykinase with an I50 of 0.3 microM when excess FeCl2 was present. No inhibition occurred in the absence of added metal ion. Inhibition was partial and noncompetitive versus ITP and oxalacetic acid.
Henry A. Lardy, Margaret Laue Merryfield
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Phosphoenolpyruvate carboxykinase activity in invertebrates
Comparative Biochemistry and Physiology, 1964Abstract 1. 1. The presence of P-enolpyruvate carboxykinase has been demonstrated in nine species of molluscs and one species of coelenterate. In most, the activity was considerably higher than in rat liver and in some of them the activity was much higher than in chicken liver. 2. 2.
Jorge Awapara, John W. Simpson
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Stereochemistry of phosphoenolpyruvate carboxylation catalyzed by phosphoenolpyruvate carboxykinase
Biochemistry, 1986The stereochemistry of the carboxylation of phosphoenolpyruvate to yield oxalacetate, catalyzed by chicken liver phosphoenolpyruvate carboxykinase and by Ascaris muscle phosphoenolpyruvate carboxykinase, was determined. The substrate (Z)-3-fluorophosphoenolpyruvate was used for the stereochemical analysis.
Seung Hee Hwang, Thomas Nowak
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Phosphoenolpyruvate carboxykinase and gluconeogenesis in grape pericarp
Plant Physiology and Biochemistry, 2015Glycolysis from sugars is necessary at all stages of development of grape pericarp, and this raises the question as to why gluconeogenesis from malate occurs. Phosphoenolpyruvate carboxykinase (PEPCK) is required for gluconeogenesis in grape pericarp.
Walker, Robert P. +5 more
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TWO CASES OF PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY
Acta Paediatrica, 1976ABSTRACT. Two children are described who suffered from hypoglycemia and liver impairment. Assays of gluconeogenic enzymes in liver samples taken immediately after death demonstrated a deficiency of phosphoenolpyruvate carboxykinase, a key enzyme of gluconeogenesis.
J. D. Elema +4 more
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The kinetic mechanism of yeast phosphoenolpyruvate carboxykinase
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993The kinetic mechanism of yeast phosphoenolpyruvate carboxykinase, in the physiological direction, has been determined. Product inhibition using KHCO3 showed competitive inhibition, when both oxalacetate (OAA) and ATP were varied. Phosphoenolpyruvate showed noncompetitive inhibition against OAA, and competitive inhibition with respect to ATP. Conversely,
Ana María Jabalquinto, Emilio Cardemil
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Regulation of Gluconeogenesis at Phosphoenolpyruvate Carboxykinase
1984Publisher Summary This chapter discusses the regulation of gluconeogenesis at phosphoenolpyruvate carboxykinase. It describes the formation of phosphoenolpyruvate (P-enolpyruvate) from oxalacetate. P-enolpyruvate carboxy-kinase (PEPCK) has only a single known function but it exists in two isozyme forms in two different cellular locations and its ...
Henry A. Lardy, Peter E. Hughes
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