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The expanding landscape of the glucagon signaling network: mechanisms and outcomes.
EndocrinologyFoollee A, Wu Y, Rusu PM, Rose AJ.
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REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION
Annual Review of Biochemistry, 1997Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) is a key enzyme in the synthesis of glucose in the liver and kidney and of glyceride-glycerol in white adipose tissue and the small intestine. The gene for the cytosolic form of PEPCK (PEPCK-C) is acutely regulated by a variety of dietary and hormonal signals, which result in alteration of ...
Lea Reshef +2 more
exaly +3 more sources
Regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription
Molecular and Cellular Biochemistry, 1991Transcription of the gene for phosphoenolpyruvate carboxykinase is regulated by several hormones which control the level of glucose synthesis in vertebrate animals. A 490 bp segment located at the 5' end of the structural gene contains the necessary regulatory elements to account for the pattern of transcriptional regulation characteristic of the ...
R W Hanson, R W Hanson
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Cyclic AMP and the synthesis of phosphoenolpyruvate carboxykinase (GTP) mRNA
Trends in Biochemical Sciences, 1983The regulation of cytosolic phosphoenolpyruvate carboxykinase RNA by cyclic-AMP-dependent hormones is discussed, with special emphasis on transcriptional control in isolated nuclei. A model is proposed to account for stimulation of phosphoenolpyruvate carboxykinase RNA synthesis by cyclic AMP.
Wouter H Lamers +2 more
exaly +2 more sources
Journal of Molecular Biology, 2002
We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependent PEPCK, and provide the first view of a novel GTP-binding site unique to the GTP-dependent PEPCK family.
Hanspeter Michel
exaly +3 more sources
We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependent PEPCK, and provide the first view of a novel GTP-binding site unique to the GTP-dependent PEPCK family.
Hanspeter Michel
exaly +3 more sources
Bioorganic and Medicinal Chemistry Letters, 2003
The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover orally active compounds that improve glucose homeostasis in Type 2 diabetics by reversibly inhibiting PEPCK led to the discovery of 1-allyl-3-butyl-8-methylxanthine (5).
Louise H, Foley +5 more
exaly +3 more sources
The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover orally active compounds that improve glucose homeostasis in Type 2 diabetics by reversibly inhibiting PEPCK led to the discovery of 1-allyl-3-butyl-8-methylxanthine (5).
Louise H, Foley +5 more
exaly +3 more sources
Biochemistry, 1985
The effect of hormones on the transcription rate of cytosolic phosphoenolpyruvate carboxykinase and level of mRNA for this enzyme in the rat kidney has been investigated. In renal nuclei isolated from rats given dibutyryladenosine cyclic 3',5'-phosphate (Bt2cAMP) or 8-bromoadenosine cyclic 3',5'-phosphate (8-Br-cAMP), [32P]UMP incorporation into ...
Herman Meisner +2 more
exaly +3 more sources
The effect of hormones on the transcription rate of cytosolic phosphoenolpyruvate carboxykinase and level of mRNA for this enzyme in the rat kidney has been investigated. In renal nuclei isolated from rats given dibutyryladenosine cyclic 3',5'-phosphate (Bt2cAMP) or 8-bromoadenosine cyclic 3',5'-phosphate (8-Br-cAMP), [32P]UMP incorporation into ...
Herman Meisner +2 more
exaly +3 more sources
Conservation from rat to human of cytosolic phosphoenolpyruvate carboxykinase and the control of its gene expression [PDF]
FEBS Letters, 1985 Structural conservation of cytosolic phosphoenolpyruvate carboxykinase protein and mRNA sequence was found in all species examined from rodents to human. The mitochondrial isoenzyme, in all species tested, represents a distinct protein.
Nissim Benvenisty +2 more
exaly +2 more sources