Synthesis of phosphoenolpyruvate carboxykinase (guanosine triphosphate) by isolated liver polyribosomes [PDF]
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Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues [PDF]
F J Ballard +4 more
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Regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription
Molecular and Cellular Biochemistry, 1991Transcription of the gene for phosphoenolpyruvate carboxykinase is regulated by several hormones which control the level of glucose synthesis in vertebrate animals. A 490 bp segment located at the 5' end of the structural gene contains the necessary regulatory elements to account for the pattern of transcriptional regulation characteristic of the ...
Jinsong Liu, R. W. Hanson
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REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION
Annual Review of Biochemistry, 1997Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) is a key enzyme in the synthesis of glucose in the liver and kidney and of glyceride-glycerol in white adipose tissue and the small intestine. The gene for the cytosolic form of PEPCK (PEPCK-C) is acutely regulated by a variety of dietary and hormonal signals, which result in alteration of ...
Lea Reshef, Richard W. Hanson
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Cyclic AMP and the synthesis of phosphoenolpyruvate carboxykinase (GTP) mRNA
Trends in Biochemical Sciences, 1983The regulation of cytosolic phosphoenolpyruvate carboxykinase RNA by cyclic-AMP-dependent hormones is discussed, with special emphasis on transcriptional control in isolated nuclei. A model is proposed to account for stimulation of phosphoenolpyruvate carboxykinase RNA synthesis by cyclic AMP.
Herman Meisner +2 more
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Photochemical cross-linking of guanosine 5'-triphosphate to phosphoenolpyruvate carboxykinase (GTP)
Bioconjugate Chemistry, 1992Mammalian phosphoenolpyruvate carboxykinase (PEPCK) specifically requires a guanosine or inosine nucleotide as a substrate; however, the structural basis for this nucleotide specificity is not yet known. Because affinity labels derived from guanosine have not yielded a stable, modified peptide in quantities sufficient for sequence analysis, we have ...
Cristina T. Lewis +2 more
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Insulin and glucagon regulate cytosolic phosphoenolpyruvate carboxykinase (GTP) mRNA in rat liver
Diabetes, 1984Insulin causes a 7–10-fold decrease of both the mRNA that codes for rat hepatic phosphoenolpyruvate carboxykinase (mRNAPEPCK) and of PEPCK synthesis, provided the animals are made diabetic and fed chow. mRNAPEPCK, measured either by in vitro translation or cDNA hybridization, decreases with a half-time of 30–60 min after insulin treatment.
Mark A. Granner +4 more
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The cytosolic form of phosphoenolpyruvate carboxykinase (GTP; EC 4.1.1.32) from rat liver was purified by a procedure involving affinity chromatography on agarose-hydrazide-GTP. Phosphoenolpyruvate carboxykinase is retained quantitatively by the affinity medium in the presence of manganese and can be specifically eluted by a pulse of GTP.
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Partial Purification and Characterization of Rat-Liver Messenger RNA Coding for Phosphoenolpyruvate Carboxykinase (GTP) [PDF]
European Journal of Biochemistry, 1978 The mRNA coding for the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) was partially purified from the liver of cyclic-AMP-treated rats by a procedure involving multiple oligo(dT)-cellulose chromatographies and sucrose gradient fractionations.
Patrick B. Iynedjian, Richard W. Hanson
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