Results 201 to 210 of about 10,168 (226)
Partial Purification and Characterization of Rat-Liver Messenger RNA Coding for Phosphoenolpyruvate Carboxykinase (GTP) [PDF]
European Journal of Biochemistry, 1978 The mRNA coding for the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) was partially purified from the liver of cyclic-AMP-treated rats by a procedure involving multiple oligo(dT)-cellulose chromatographies and sucrose gradient fractionations.
Patrick B. Iynedjian, Richard W. Hanson
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Advances in Enzyme Regulation, 1981
As can be seen from the data presented in this chapter, glucagon, epinephrine and Bt2cAMP can act directly on isolated rat hepatocytes to markedly increase the concentration of P-enolpyruvate carboxykinase mRNA. The effects of these hormones on enzyme mRNa are rapid, causing a 2–3-fold increase in 90 min of incubation.
Philip van Lelyveld +2 more
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As can be seen from the data presented in this chapter, glucagon, epinephrine and Bt2cAMP can act directly on isolated rat hepatocytes to markedly increase the concentration of P-enolpyruvate carboxykinase mRNA. The effects of these hormones on enzyme mRNa are rapid, causing a 2–3-fold increase in 90 min of incubation.
Philip van Lelyveld +2 more
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Bioorganic & Medicinal Chemistry Letters, 2003
The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover orally active compounds that improve glucose homeostasis in Type 2 diabetics by reversibly inhibiting PEPCK led to the discovery of 1-allyl-3-butyl-8-methylxanthine (5).
Gwendolyn Ramsey +5 more
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The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover orally active compounds that improve glucose homeostasis in Type 2 diabetics by reversibly inhibiting PEPCK led to the discovery of 1-allyl-3-butyl-8-methylxanthine (5).
Gwendolyn Ramsey +5 more
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Developmental & Comparative Immunology, 2017
Phosphoenolpyruvate carboxykinase (PEPCK) is well known as a key enzyme involved in the metabolic pathway of gluconeogenesis in organisms, but the information about its involvement in immune response is still very limited. In the present study, a novel PEPCK homolog named CgPEPCK was identified from oyster Crassostrea gigas.
Zhao Lv +9 more
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Phosphoenolpyruvate carboxykinase (PEPCK) is well known as a key enzyme involved in the metabolic pathway of gluconeogenesis in organisms, but the information about its involvement in immune response is still very limited. In the present study, a novel PEPCK homolog named CgPEPCK was identified from oyster Crassostrea gigas.
Zhao Lv +9 more
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Archives of Biochemistry and Biophysics, 1975
Abstract In vitro , 3-mercaptopicolinic acid inhibited phosphoenolpyruvate carboxykinase activity in supernatant fractions of liver, kidney cortex, and adipose tissue obtained from fasted rats. 3-Mercaptopicolinic acid also inhibited enzymatic activity in the mitochondrial and supernatant fractions of liver obtained from fasted guinea pigs.
L. Cieslinski +4 more
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Abstract In vitro , 3-mercaptopicolinic acid inhibited phosphoenolpyruvate carboxykinase activity in supernatant fractions of liver, kidney cortex, and adipose tissue obtained from fasted rats. 3-Mercaptopicolinic acid also inhibited enzymatic activity in the mitochondrial and supernatant fractions of liver obtained from fasted guinea pigs.
L. Cieslinski +4 more
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Journal of Molecular Biology, 2002
We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependent PEPCK, and provide the first view of a novel GTP-binding site unique to the GTP-dependent PEPCK family.
Hanspeter Michel +10 more
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We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependent PEPCK, and provide the first view of a novel GTP-binding site unique to the GTP-dependent PEPCK family.
Hanspeter Michel +10 more
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Somatic Cell and Molecular Genetics, 1985
The structural gene Pck-1, encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32), has been assigned to mouse chromosome 2. This assignment was made based on genomic Southern transfer of rat-mouse and hamster-mouse hybrid DNAs using a rat kidney cloned cDNA of the PEPCK gene as a probe. Conclusive evidence for the cosegregation
Janis Lem, R. E. K. Fournier
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The structural gene Pck-1, encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32), has been assigned to mouse chromosome 2. This assignment was made based on genomic Southern transfer of rat-mouse and hamster-mouse hybrid DNAs using a rat kidney cloned cDNA of the PEPCK gene as a probe. Conclusive evidence for the cosegregation
Janis Lem, R. E. K. Fournier
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Archives of Biochemistry and Biophysics, 1994
The relationship between the control by cAMP of phosphoenolpyruvate carboxykinase (GTP) mRNA synthesis and breakdown was examined. The half-life of phosphoenolpyruvate carboxykinase mRNA was estimated from its decay rate in cells exposed to insulin (a specific inhibitor of phosphoenolpyruvate carboxy-kinase gene transcription) in the presence or ...
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The relationship between the control by cAMP of phosphoenolpyruvate carboxykinase (GTP) mRNA synthesis and breakdown was examined. The half-life of phosphoenolpyruvate carboxykinase mRNA was estimated from its decay rate in cells exposed to insulin (a specific inhibitor of phosphoenolpyruvate carboxy-kinase gene transcription) in the presence or ...
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Phosphoenolpyruvate carboxykinase (ATP) [PDF]
, 1990 Margit Salzmann, Dietmar Schomburg
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Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1976
W. Guder, U. Schmidt
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W. Guder, U. Schmidt
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